Tumor suppressor genes and clonal evolution in b-CLL

Neil Elliot Kay, Erik A. Ranheim, Loann C. Peterson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This review highlights the genetic alterations that have been detailed in the malignant B-cell clones of patients with B-chronic lymphocytic leukemia (CLL). In particular, the alterations seen in p53 and the retinoblastoma (Rb) genes are reviewed. In addition, the multiplicity of cytogenetic alterations observed at baseline and on sequential analysis are summarized. The cytogenetic and molecular biologic analysis of B-CLL clones has revealed that there is a dynamic array of genetic events which occur within a B-cell clone. This latter data strongly suggests that clonal evolution may occur in B-CLL patients. However the relationship of the clonal instability to the patient's clinical course is still unclear. The relatively frequent detection of multiple tumor suppressor gene alterations in the B-CLL clones offer several interesting clues regarding the transformation event within B-CLL. A model is proposed which attempts to explain the potential contribution and interaction of p53 and Rb gene alterations in a malignant B-cell transformation.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalLeukemia and Lymphoma
Volume18
Issue number1-2
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Clonal Evolution
B-Cell Chronic Lymphocytic Leukemia
Tumor Suppressor Genes
Clone Cells
Retinoblastoma Genes
B-Lymphocytes
p53 Genes
Cytogenetics

Keywords

  • Chronic lymphocytic leukemia
  • CLL
  • Clonal evolution
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Tumor suppressor genes and clonal evolution in b-CLL. / Kay, Neil Elliot; Ranheim, Erik A.; Peterson, Loann C.

In: Leukemia and Lymphoma, Vol. 18, No. 1-2, 1995, p. 41-49.

Research output: Contribution to journalArticle

Kay, Neil Elliot ; Ranheim, Erik A. ; Peterson, Loann C. / Tumor suppressor genes and clonal evolution in b-CLL. In: Leukemia and Lymphoma. 1995 ; Vol. 18, No. 1-2. pp. 41-49.
@article{c8abd2a93e07424884f48721d686d68a,
title = "Tumor suppressor genes and clonal evolution in b-CLL",
abstract = "This review highlights the genetic alterations that have been detailed in the malignant B-cell clones of patients with B-chronic lymphocytic leukemia (CLL). In particular, the alterations seen in p53 and the retinoblastoma (Rb) genes are reviewed. In addition, the multiplicity of cytogenetic alterations observed at baseline and on sequential analysis are summarized. The cytogenetic and molecular biologic analysis of B-CLL clones has revealed that there is a dynamic array of genetic events which occur within a B-cell clone. This latter data strongly suggests that clonal evolution may occur in B-CLL patients. However the relationship of the clonal instability to the patient's clinical course is still unclear. The relatively frequent detection of multiple tumor suppressor gene alterations in the B-CLL clones offer several interesting clues regarding the transformation event within B-CLL. A model is proposed which attempts to explain the potential contribution and interaction of p53 and Rb gene alterations in a malignant B-cell transformation.",
keywords = "Chronic lymphocytic leukemia, CLL, Clonal evolution, Tumor suppressor genes",
author = "Kay, {Neil Elliot} and Ranheim, {Erik A.} and Peterson, {Loann C.}",
year = "1995",
doi = "10.3109/10428199509064921",
language = "English (US)",
volume = "18",
pages = "41--49",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "1-2",

}

TY - JOUR

T1 - Tumor suppressor genes and clonal evolution in b-CLL

AU - Kay, Neil Elliot

AU - Ranheim, Erik A.

AU - Peterson, Loann C.

PY - 1995

Y1 - 1995

N2 - This review highlights the genetic alterations that have been detailed in the malignant B-cell clones of patients with B-chronic lymphocytic leukemia (CLL). In particular, the alterations seen in p53 and the retinoblastoma (Rb) genes are reviewed. In addition, the multiplicity of cytogenetic alterations observed at baseline and on sequential analysis are summarized. The cytogenetic and molecular biologic analysis of B-CLL clones has revealed that there is a dynamic array of genetic events which occur within a B-cell clone. This latter data strongly suggests that clonal evolution may occur in B-CLL patients. However the relationship of the clonal instability to the patient's clinical course is still unclear. The relatively frequent detection of multiple tumor suppressor gene alterations in the B-CLL clones offer several interesting clues regarding the transformation event within B-CLL. A model is proposed which attempts to explain the potential contribution and interaction of p53 and Rb gene alterations in a malignant B-cell transformation.

AB - This review highlights the genetic alterations that have been detailed in the malignant B-cell clones of patients with B-chronic lymphocytic leukemia (CLL). In particular, the alterations seen in p53 and the retinoblastoma (Rb) genes are reviewed. In addition, the multiplicity of cytogenetic alterations observed at baseline and on sequential analysis are summarized. The cytogenetic and molecular biologic analysis of B-CLL clones has revealed that there is a dynamic array of genetic events which occur within a B-cell clone. This latter data strongly suggests that clonal evolution may occur in B-CLL patients. However the relationship of the clonal instability to the patient's clinical course is still unclear. The relatively frequent detection of multiple tumor suppressor gene alterations in the B-CLL clones offer several interesting clues regarding the transformation event within B-CLL. A model is proposed which attempts to explain the potential contribution and interaction of p53 and Rb gene alterations in a malignant B-cell transformation.

KW - Chronic lymphocytic leukemia

KW - CLL

KW - Clonal evolution

KW - Tumor suppressor genes

UR - http://www.scopus.com/inward/record.url?scp=0029090458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029090458&partnerID=8YFLogxK

U2 - 10.3109/10428199509064921

DO - 10.3109/10428199509064921

M3 - Article

C2 - 8580828

AN - SCOPUS:0029090458

VL - 18

SP - 41

EP - 49

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 1-2

ER -