Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer

Vijay S. Madamsetty, Anil Sharma, Maria Toma, Stefanie Samaniego, Audrey Gallud, Enfeng Wang, Krishnendu Pal, Debabrata Mukhopadhyay, Bengt Fadeel

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths and novel treatment approaches are urgently needed. Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in an orthotopic pancreatic xenograft model. ND-PEG-DOX complexes were also superior to free DOX in 3-dimensional (3D) tumor spheroids of PDAC. ND-PEG showed no cytotoxicity towards macrophages, and histopathological analysis showed no abnormalities of major organs upon in vivo administration of ND-PEG-DOX. These results provide evidence that ND-mediated drug delivery may serve as a means of improving the therapeutic outcome in PDAC.

Original languageEnglish (US)
Pages (from-to)112-121
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume18
DOIs
StatePublished - Jun 2019

Keywords

  • Drug delivery
  • Nanodiamonds
  • Nanomedicine
  • Pancreatic adenocarcinoma

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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