TY - JOUR
T1 - Tumor-infiltrating dendritic cells in cancer pathogenesis
AU - Janco, Jo Marie Tran
AU - Lamichhane, Purushottam
AU - Karyampudi, Lavakumar
AU - Knutson, Keith L.
N1 - Publisher Copyright:
Copyright © 2015 by The American Association of Immunologists, Inc.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immunestimulatory capacity.
AB - Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immunestimulatory capacity.
UR - http://www.scopus.com/inward/record.url?scp=84925872136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925872136&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1403134
DO - 10.4049/jimmunol.1403134
M3 - Review article
C2 - 25795789
AN - SCOPUS:84925872136
SN - 0022-1767
VL - 194
SP - 2985
EP - 2991
JO - Journal of Immunology
JF - Journal of Immunology
IS - 7
ER -