Tumor-infiltrating dendritic cells in cancer pathogenesis

Jo Marie Tran Janco, Purushottam Lamichhane, Lavakumar Karyampudi, Keith L. Knutson

Research output: Contribution to journalReview article

156 Scopus citations

Abstract

Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immunestimulatory capacity.

Original languageEnglish (US)
Pages (from-to)2985-2991
Number of pages7
JournalJournal of Immunology
Volume194
Issue number7
DOIs
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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