Tumor-infiltrating dendritic cells in cancer pathogenesis

Jo Marie Tran Janco, Purushottam Lamichhane, Lavakumar Karyampudi, Keith L Knutson

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immunestimulatory capacity.

Original languageEnglish (US)
Pages (from-to)2985-2991
Number of pages7
JournalJournal of Immunology
Volume194
Issue number7
DOIs
StatePublished - Apr 1 2015

Fingerprint

Dendritic Cells
Neoplasms
Tumor Microenvironment
Immune System Diseases
Immunosuppressive Agents
Disease Progression
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Tumor-infiltrating dendritic cells in cancer pathogenesis. / Janco, Jo Marie Tran; Lamichhane, Purushottam; Karyampudi, Lavakumar; Knutson, Keith L.

In: Journal of Immunology, Vol. 194, No. 7, 01.04.2015, p. 2985-2991.

Research output: Contribution to journalArticle

Janco, Jo Marie Tran ; Lamichhane, Purushottam ; Karyampudi, Lavakumar ; Knutson, Keith L. / Tumor-infiltrating dendritic cells in cancer pathogenesis. In: Journal of Immunology. 2015 ; Vol. 194, No. 7. pp. 2985-2991.
@article{89057594b01a4f83b7b39c3bcd15a7dc,
title = "Tumor-infiltrating dendritic cells in cancer pathogenesis",
abstract = "Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immunestimulatory capacity.",
author = "Janco, {Jo Marie Tran} and Purushottam Lamichhane and Lavakumar Karyampudi and Knutson, {Keith L}",
year = "2015",
month = "4",
day = "1",
doi = "10.4049/jimmunol.1403134",
language = "English (US)",
volume = "194",
pages = "2985--2991",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "7",

}

TY - JOUR

T1 - Tumor-infiltrating dendritic cells in cancer pathogenesis

AU - Janco, Jo Marie Tran

AU - Lamichhane, Purushottam

AU - Karyampudi, Lavakumar

AU - Knutson, Keith L

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immunestimulatory capacity.

AB - Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immunestimulatory capacity.

UR - http://www.scopus.com/inward/record.url?scp=84925872136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925872136&partnerID=8YFLogxK

U2 - 10.4049/jimmunol.1403134

DO - 10.4049/jimmunol.1403134

M3 - Article

C2 - 25795789

AN - SCOPUS:84925872136

VL - 194

SP - 2985

EP - 2991

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 7

ER -