Tumor imaging via indium 111-labeled DTPA-adenosylcobalamin

D. A. Collins, H. P C Hogenkamp, M. W. Geshard

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Vitamin B12 is essential for life. Lack of it results in pernicious anemia and death. Conversely, the demand for vitamin B12 increases in rapidly dividing tumors. This is secondary to the direct involvement of vitamin B12 in mitochondrial metabolism as well as its indirect role in the production of thymidylate and S-adenosylmethionine. The latter 2 substances are needed for DNA synthesis and cellular methylation reactions, respectively. Novel radiolabeling of adenosylcobalamin has proven to be useful in the imaging of transplanted and spontaneous tumors in animals. Herein, we describe what we believe to be the first human to have imaging with conventional gamma cameras of vitamin B12 metabolism in a breast tumor.

Original languageEnglish (US)
Pages (from-to)687-691
Number of pages5
JournalMayo Clinic Proceedings
Volume74
Issue number7
StatePublished - 1999

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Pentetic Acid
Indium
Vitamin B 12
Neoplasms
Pernicious Anemia
S-Adenosylmethionine
Gamma Cameras
Methylation
Breast Neoplasms
cobamamide
DNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Collins, D. A., Hogenkamp, H. P. C., & Geshard, M. W. (1999). Tumor imaging via indium 111-labeled DTPA-adenosylcobalamin. Mayo Clinic Proceedings, 74(7), 687-691.

Tumor imaging via indium 111-labeled DTPA-adenosylcobalamin. / Collins, D. A.; Hogenkamp, H. P C; Geshard, M. W.

In: Mayo Clinic Proceedings, Vol. 74, No. 7, 1999, p. 687-691.

Research output: Contribution to journalArticle

Collins, DA, Hogenkamp, HPC & Geshard, MW 1999, 'Tumor imaging via indium 111-labeled DTPA-adenosylcobalamin', Mayo Clinic Proceedings, vol. 74, no. 7, pp. 687-691.
Collins DA, Hogenkamp HPC, Geshard MW. Tumor imaging via indium 111-labeled DTPA-adenosylcobalamin. Mayo Clinic Proceedings. 1999;74(7):687-691.
Collins, D. A. ; Hogenkamp, H. P C ; Geshard, M. W. / Tumor imaging via indium 111-labeled DTPA-adenosylcobalamin. In: Mayo Clinic Proceedings. 1999 ; Vol. 74, No. 7. pp. 687-691.
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