Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung

Jennifer M. Boland, Eugene D. Kwon, Susan M. Harrington, Jason A. Wampfler, Hui Tang, Ping Yang, Marie Christine Aubry

Research output: Contribution to journalArticle

141 Scopus citations

Abstract

Background: Pulmonary squamous cell carcinoma has a poor prognosis, and new therapeutic targets are needed. The aberrant expression of the immunomodulatory proteins B7-H1 and B7-H3 by malignant cells may contribute to tumoral immune evasion. Data about the expression of these proteins by squamous cell carcinoma of the lung are limited. Materials and Methods: Immunohistochemistry for B7-H1 and B7-H3 was performed on 214 resected pulmonary squamous cell carcinoma specimens. Results: At the last follow-up, 171 of 214 (80%) of patients were deceased (median survival time, 3.76 years). Forty-two (19.6%) of 214 cases showed positivity with B7-H1, with a range of 5% to 60% of cells that stained positively. A total of 189 (88.3%) of 214 cases showed positivity with B7-H3, with a range of 5% to 80% of cells staining positively. By using multivariate analysis, no degree of B7-H1 or B7-H3 positivity was significantly associated with patient outcome. Conclusions: Although B7-H1 and B7-H3 are not of independent prognostic value, they are commonly expressed on a subset of tumor cells in pulmonary squamous cell carcinomas. Known interaction of the B7-H proteins with cytotoxic T-lymphocyte antigen-4 may make them attractive candidate biomarkers for response to immunomodulatory therapeutics, eg, ipilimumab, and warrants further study.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalClinical Lung Cancer
Volume14
Issue number2
DOIs
StatePublished - Mar 1 2013

Keywords

  • B7-H1
  • B7-H3
  • Lung cancer
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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    Boland, J. M., Kwon, E. D., Harrington, S. M., Wampfler, J. A., Tang, H., Yang, P., & Aubry, M. C. (2013). Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung. Clinical Lung Cancer, 14(2), 157-163. https://doi.org/10.1016/j.cllc.2012.05.006