Tumefactive demyelination and glioblastoma: A rare collision lesion

S. F. Roemer, B. W. Scheithauer, G. G. Varnavas, Claudia F Lucchinetti

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: Inflammatory demyelination occasionally forms a solitary mass lesion clinically and radiographically indistinguishable from glioma, replete with enhancement and mass effect. Termed "tumefactive demyelination" it often prompts a brain biopsy. Design: We undertook neuroimaging and morphologic analysis of a unifocal demyelinating lesion intimately associated with glioblastoma. MRI characteristics of the lesion were assessed as were biopsy and resection specimens by both histological and immunohistochemical methods. Results: The patient, a 49-year-old woman, presented with subacute onset headaches. An MRI T1W scan revealed a hemispheric mass with centrally reduced signal and ring enhancement. T2W images showed increased central signal with a rim of reduced signal co-localized to the enhancing ring. A biopsy was initially misinterpreted as demyelination alone, given abundance of histiocytes, the presence of hypertrophic astrocytes with micronuclei ("Creutzfeldt-Peters cells"), and occasional mitoses. Upon consultative review, two histologically distinct components, one inflammatory demyelination and the other an anaplastic astrocytoma were revealed. Subsequent complete resection of the abnormality demonstrated a WHO grade IV astrocytoma (glioblastoma multiforme). Conclusion: Our experience underscores the importance of adequate tissue sampling during biopsy for suspected glioma, and confirms the fact that active inflammatory demyelination may coexist with a high-grade glioma. Despite detailed study, the basis for the association remains elusive.

Original languageEnglish (US)
Pages (from-to)186-191
Number of pages6
JournalClinical Neuropathology
Volume30
Issue number4
DOIs
StatePublished - Oct 2011

Fingerprint

Demyelinating Diseases
Glioblastoma
Glioma
Biopsy
Histiocytes
Astrocytoma
Mitosis
Neuroimaging
Astrocytes
Headache
Magnetic Resonance Imaging
Brain

Keywords

  • Brain neoplasm
  • Inflammatory demyelination
  • Neoplastic transformation
  • Tumefactive demyelinating disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neurology

Cite this

Tumefactive demyelination and glioblastoma : A rare collision lesion. / Roemer, S. F.; Scheithauer, B. W.; Varnavas, G. G.; Lucchinetti, Claudia F.

In: Clinical Neuropathology, Vol. 30, No. 4, 10.2011, p. 186-191.

Research output: Contribution to journalArticle

Roemer, S. F. ; Scheithauer, B. W. ; Varnavas, G. G. ; Lucchinetti, Claudia F. / Tumefactive demyelination and glioblastoma : A rare collision lesion. In: Clinical Neuropathology. 2011 ; Vol. 30, No. 4. pp. 186-191.
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