Tudor Domains as Methyl-Lysine and Methyl-Arginine Readers

Maria Victoria Botuyan, Georges Mer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The Tudor domain is a methyl-lysine and methyl-arginine binding domain present in proteins involved in cellular functions as diverse as DNA transcription, RNA metabolism, gene silencing, the transmission of epigenetic posttranslational modifications, and the maintenance of genomic stability. In this chapter, we review the different forms-single Tudor, tandem Tudor, hybrid Tudor, extended Tudor-and substrate binding modes, including methylation-state specificity, of the Tudor domain. Our focus is on proteins for which three-dimensional structures of Tudor domains in complex with lysine- or arginine-methylated substrates are available. The functional significance of Tudor proteins in chromatin signaling and possible involvement in diseases are highlighted.

Original languageEnglish (US)
Title of host publicationChromatin Signaling and Diseases
PublisherElsevier Inc.
Pages149-165
Number of pages17
ISBN (Electronic)9780128026090
ISBN (Print)9780128023891
DOIs
StatePublished - Aug 24 2016

Fingerprint

Lysine
Arginine
Proteins
Methylation
Genomic Instability
Gene Silencing
Substrates
Transcription
Post Translational Protein Processing
Metabolism
Epigenomics
Chromatin
Genes
Maintenance
RNA
DNA
Tudor Domain

Keywords

  • DNA damage response
  • DNA transcription
  • Epigenetics
  • Gene silencing
  • Methyl-arginine
  • Methyl-lysine
  • Non-coding RNA
  • Royal Family
  • Tudor domain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Botuyan, M. V., & Mer, G. (2016). Tudor Domains as Methyl-Lysine and Methyl-Arginine Readers. In Chromatin Signaling and Diseases (pp. 149-165). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802389-1.00008-3

Tudor Domains as Methyl-Lysine and Methyl-Arginine Readers. / Botuyan, Maria Victoria; Mer, Georges.

Chromatin Signaling and Diseases. Elsevier Inc., 2016. p. 149-165.

Research output: Chapter in Book/Report/Conference proceedingChapter

Botuyan, MV & Mer, G 2016, Tudor Domains as Methyl-Lysine and Methyl-Arginine Readers. in Chromatin Signaling and Diseases. Elsevier Inc., pp. 149-165. https://doi.org/10.1016/B978-0-12-802389-1.00008-3
Botuyan MV, Mer G. Tudor Domains as Methyl-Lysine and Methyl-Arginine Readers. In Chromatin Signaling and Diseases. Elsevier Inc. 2016. p. 149-165 https://doi.org/10.1016/B978-0-12-802389-1.00008-3
Botuyan, Maria Victoria ; Mer, Georges. / Tudor Domains as Methyl-Lysine and Methyl-Arginine Readers. Chromatin Signaling and Diseases. Elsevier Inc., 2016. pp. 149-165
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