Tubulointerstitial nephritis and other renal involvement by IgG4-related disease

Lynn D. Cornell, Naoki Takahashi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

IgG4-related kidney disease (IgG4-RKD) is a collective term used to describe the different types of renal involvement seen in IgG4-related disease (IgG4-RD). IgG4-RD is a recently described systemic immune-mediated disease that can involve nearly any organ system. The best-recognized form of IgG4-RKD is IgG4-related tubulointerstitial nephritis (IgG4-TIN), which may present as renal failure, renal mass lesions, or both. Radiographically, renal lesions are commonly bilateral and multiple, predominantly involving renal cortex, and can mimic a neoplasm. On tissue sections, IgG4-TIN is characterized by a plasma cell-rich interstitial inflammatory cell infiltrate, often with numerous eosinophils, and typically accompanied by storiform fibrosis; these features are strikingly similar to the fibroinflammatory lesions seen in other organs affected by IgG4-RD. In the majority of cases of IgG4-TIN, tubular basement membrane immune complex deposits, a useful feature to help distinguish IgG4-TIN from other forms of tubulointerstitial nephritis, can be seen by immunofluorescence or electron microscopy studies. The histopathologic, immunophenotypic, ultrastructural, and radiographic features of IgG4-related tubulointerstitial nephritis are reviewed here. Glomerular disease can also be associated with IgG4-RD, most commonly membranous glomerulonephritis, which may occur with or without concurrent IgG4-TIN.

Original languageEnglish (US)
Title of host publicationAutoimmune (IgG4-Related) Pancreatitis and Cholangitis
PublisherSpringer New York
Pages189-197
Number of pages9
ISBN (Print)9781441964304, 1441964290, 9781441964298
DOIs
StatePublished - Feb 1 2014

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cornell, L. D., & Takahashi, N. (2014). Tubulointerstitial nephritis and other renal involvement by IgG4-related disease. In Autoimmune (IgG4-Related) Pancreatitis and Cholangitis (pp. 189-197). Springer New York. https://doi.org/10.1007/978-1-4419-6430-4_18