Tubulointerstitial injury: Signaling pathways, inflammation, fibrogenesis

Stella P. Hartono, Joseph Peter Grande

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Renovascular hypertension (RVH) is an important cause of both renal and cardiovascular morbidity and mortality. Atherosclerosis is the most common etiology underlying the development of RVH. In the stenotic kidney, the development of interstitial fibrosis and tubular atrophy is associated with the influx of inflammatory cells. These morphologic alterations result from a complex interplay of several pathways involving the renin angiotensin system, oxidative stress, the TGF-β-Smad signaling pathway, and the mitogen-activated protein kinase (MAPK) pathway, leading to both local and systemic production of chemokines that promote ongoing inflammation and interstitial fibrosis. In this chapter, we will summarize recent human and experimental studies to determine how these signaling pathways interact and contribute to renal inflammation and fibrogenesis. Identification of these pathways will provide a mechanistic basis for the development of RVH and may provide the basis for novel therapeutic targets directed towards arresting the progression of renal disease in patients with renal artery stenosis.

Original languageEnglish (US)
Title of host publicationRenal Vascular Disease
PublisherSpringer-Verlag London Ltd
Pages173-186
Number of pages14
Volume9781447128106
ISBN (Print)9781447128106, 1447128095, 9781447128090
DOIs
StatePublished - Dec 1 2014

Fingerprint

Renovascular Hypertension
Inflammation
Kidney
Wounds and Injuries
Fibrosis
Renal Artery Obstruction
Renin-Angiotensin System
Mitogen-Activated Protein Kinases
Chemokines
Atrophy
Disease Progression
Atherosclerosis
Oxidative Stress
Morbidity
Mortality
Therapeutics

Keywords

  • CCL2
  • Fibrosis
  • Inflammation
  • Macrophage
  • MAPK
  • Renal artery stenosis
  • TGF-Β

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hartono, S. P., & Grande, J. P. (2014). Tubulointerstitial injury: Signaling pathways, inflammation, fibrogenesis. In Renal Vascular Disease (Vol. 9781447128106, pp. 173-186). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-2810-6_10

Tubulointerstitial injury : Signaling pathways, inflammation, fibrogenesis. / Hartono, Stella P.; Grande, Joseph Peter.

Renal Vascular Disease. Vol. 9781447128106 Springer-Verlag London Ltd, 2014. p. 173-186.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hartono, SP & Grande, JP 2014, Tubulointerstitial injury: Signaling pathways, inflammation, fibrogenesis. in Renal Vascular Disease. vol. 9781447128106, Springer-Verlag London Ltd, pp. 173-186. https://doi.org/10.1007/978-1-4471-2810-6_10
Hartono SP, Grande JP. Tubulointerstitial injury: Signaling pathways, inflammation, fibrogenesis. In Renal Vascular Disease. Vol. 9781447128106. Springer-Verlag London Ltd. 2014. p. 173-186 https://doi.org/10.1007/978-1-4471-2810-6_10
Hartono, Stella P. ; Grande, Joseph Peter. / Tubulointerstitial injury : Signaling pathways, inflammation, fibrogenesis. Renal Vascular Disease. Vol. 9781447128106 Springer-Verlag London Ltd, 2014. pp. 173-186
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