TY - JOUR
T1 - Tubulointerstitial Changes as a Major Determinant in the Progression of Renal Damage
AU - Nath, Karl A.
PY - 1992
Y1 - 1992
N2 - Tubulointerstitial injury is an invariant finding in the chronically diseased kidney, irrespective of the type of disease or the compartment in which the disease originates. Such histologic changes are functionally significant in that scores for such damage, rather than glomerular injury, correlate with decline of renal function. This review summarizes (1) clinical evidence attesting to tubulointerstitial changes as an index of functional impairment, (2) mechanisms by which tubulointerstitial injury impairs renal function, and (3) interactions of pathologic processes in the vascular, glomerular, tubular, and interstitial compartments that culminate in tubulointerstitial injury. This report concludes with a review of interstitial fibrosis, a pathologic process regarded as an irreversible outcome from tubulointerstitial injury.
AB - Tubulointerstitial injury is an invariant finding in the chronically diseased kidney, irrespective of the type of disease or the compartment in which the disease originates. Such histologic changes are functionally significant in that scores for such damage, rather than glomerular injury, correlate with decline of renal function. This review summarizes (1) clinical evidence attesting to tubulointerstitial changes as an index of functional impairment, (2) mechanisms by which tubulointerstitial injury impairs renal function, and (3) interactions of pathologic processes in the vascular, glomerular, tubular, and interstitial compartments that culminate in tubulointerstitial injury. This report concludes with a review of interstitial fibrosis, a pathologic process regarded as an irreversible outcome from tubulointerstitial injury.
KW - Tubulointerstitial disease
KW - fibrosis
KW - inflammation
KW - interstitium
KW - progression
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U2 - 10.1016/S0272-6386(12)80312-X
DO - 10.1016/S0272-6386(12)80312-X
M3 - Review article
C2 - 1621674
AN - SCOPUS:0026769228
SN - 0272-6386
VL - 20
SP - 1
EP - 17
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 1
ER -