Tubular dysfunction in the deeply jaundiced patient with hepatorenal syndrome

W. G. Rector, G. C. Kanel, Jorge Rakela, T. B. Reynolds

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We examined β2-microglobulin (B2MG) excretion, an index of tubular function, in patients with hepatorenal syndrome, in whom tubular function is generally regarded as normal. Urine B2MG was significantly higher in these patients than in control patients with normal serum creatinine concentration. Patients with high urine B2MG concentration had markedly higher serum bilirubin than did patients with normal values (31 ± 3 vs 10 ± 8 mg%, p < 0.001), whereas prothrombin activity, serum albumin and serum B2MG concentration were similar. A 'threshold' serum bilirubin concentration of about 23 mg% differentiated patients with normal and high urine B2MG values. Renal morphology at autopsy was unremarkable in both groups. Tubular dysfunction, manifested by increased urinary excretion of B2MG, occurs in patients with hepatorenal syndrome and deep jaundice. This measurement cannot, therefore, be used to make a diagnosis of acute tubular injury, as due to aminoglycosides, in such patients.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalHepatology
Volume5
Issue number2
StatePublished - 1985
Externally publishedYes

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Hepatorenal Syndrome
Jaundice
Urine
Serum
Bilirubin
Aminoglycosides
Prothrombin
Serum Albumin
Autopsy
Creatinine
Reference Values
Kidney

ASJC Scopus subject areas

  • Hepatology

Cite this

Rector, W. G., Kanel, G. C., Rakela, J., & Reynolds, T. B. (1985). Tubular dysfunction in the deeply jaundiced patient with hepatorenal syndrome. Hepatology, 5(2), 321-326.

Tubular dysfunction in the deeply jaundiced patient with hepatorenal syndrome. / Rector, W. G.; Kanel, G. C.; Rakela, Jorge; Reynolds, T. B.

In: Hepatology, Vol. 5, No. 2, 1985, p. 321-326.

Research output: Contribution to journalArticle

Rector, WG, Kanel, GC, Rakela, J & Reynolds, TB 1985, 'Tubular dysfunction in the deeply jaundiced patient with hepatorenal syndrome', Hepatology, vol. 5, no. 2, pp. 321-326.
Rector, W. G. ; Kanel, G. C. ; Rakela, Jorge ; Reynolds, T. B. / Tubular dysfunction in the deeply jaundiced patient with hepatorenal syndrome. In: Hepatology. 1985 ; Vol. 5, No. 2. pp. 321-326.
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