Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy

W. Bosch, N. Poowanawittayakom, K. Chaikriangkrai, Julio C Mendez, W. C. Hellinger, T. A. Gonwa, M. Krishna, Surakit Pungpapong

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Mycobacterium tuberculosis infection is one of many opportunistic infections in renal transplant recipients, arising either from reactivation of latent infection or de novo infection, occasionally donor derived. M. tuberculosis hepatitis has never been reported in patients who have received alemtuzumab as part of their renal transplant management. We describe 2 patients who underwent deceased-donor renal transplantation following alemtuzumab induction therapy and presented with a febrile syndrome, subsequently diagnosed as tuberculous hepatitis, one with disseminated disease. Both responded well to treatment without significant side effects, resulting in excellent graft function. The importance of chemoprophylaxis should be emphasized to minimize the risk of developing active tuberculosis in patients with latent tuberculosis infection undergoing solid organ transplantation.

Original languageEnglish (US)
JournalTransplant Infectious Disease
Volume15
Issue number1
DOIs
StatePublished - Feb 2013

Fingerprint

Hepatitis
Kidney
Mycobacterium tuberculosis
Tissue Donors
Latent Tuberculosis
Transplants
Mycobacterium Infections
Opportunistic Infections
Chemoprevention
Organ Transplantation
Infection
Kidney Transplantation
Tuberculosis
Fever
Therapeutics
Transplant Recipients
alemtuzumab

Keywords

  • Alemtuzumab
  • Hepatitis
  • Liver abscess
  • Renal transplantation
  • Tuberculosis

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy. / Bosch, W.; Poowanawittayakom, N.; Chaikriangkrai, K.; Mendez, Julio C; Hellinger, W. C.; Gonwa, T. A.; Krishna, M.; Pungpapong, Surakit.

In: Transplant Infectious Disease, Vol. 15, No. 1, 02.2013.

Research output: Contribution to journalArticle

Bosch, W. ; Poowanawittayakom, N. ; Chaikriangkrai, K. ; Mendez, Julio C ; Hellinger, W. C. ; Gonwa, T. A. ; Krishna, M. ; Pungpapong, Surakit. / Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy. In: Transplant Infectious Disease. 2013 ; Vol. 15, No. 1.
@article{a94f75c9992241fd83d61b6b676caaa8,
title = "Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy",
abstract = "Mycobacterium tuberculosis infection is one of many opportunistic infections in renal transplant recipients, arising either from reactivation of latent infection or de novo infection, occasionally donor derived. M. tuberculosis hepatitis has never been reported in patients who have received alemtuzumab as part of their renal transplant management. We describe 2 patients who underwent deceased-donor renal transplantation following alemtuzumab induction therapy and presented with a febrile syndrome, subsequently diagnosed as tuberculous hepatitis, one with disseminated disease. Both responded well to treatment without significant side effects, resulting in excellent graft function. The importance of chemoprophylaxis should be emphasized to minimize the risk of developing active tuberculosis in patients with latent tuberculosis infection undergoing solid organ transplantation.",
keywords = "Alemtuzumab, Hepatitis, Liver abscess, Renal transplantation, Tuberculosis",
author = "W. Bosch and N. Poowanawittayakom and K. Chaikriangkrai and Mendez, {Julio C} and Hellinger, {W. C.} and Gonwa, {T. A.} and M. Krishna and Surakit Pungpapong",
year = "2013",
month = "2",
doi = "10.1111/tid.12048",
language = "English (US)",
volume = "15",
journal = "Transplant Infectious Disease",
issn = "1398-2273",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy

AU - Bosch, W.

AU - Poowanawittayakom, N.

AU - Chaikriangkrai, K.

AU - Mendez, Julio C

AU - Hellinger, W. C.

AU - Gonwa, T. A.

AU - Krishna, M.

AU - Pungpapong, Surakit

PY - 2013/2

Y1 - 2013/2

N2 - Mycobacterium tuberculosis infection is one of many opportunistic infections in renal transplant recipients, arising either from reactivation of latent infection or de novo infection, occasionally donor derived. M. tuberculosis hepatitis has never been reported in patients who have received alemtuzumab as part of their renal transplant management. We describe 2 patients who underwent deceased-donor renal transplantation following alemtuzumab induction therapy and presented with a febrile syndrome, subsequently diagnosed as tuberculous hepatitis, one with disseminated disease. Both responded well to treatment without significant side effects, resulting in excellent graft function. The importance of chemoprophylaxis should be emphasized to minimize the risk of developing active tuberculosis in patients with latent tuberculosis infection undergoing solid organ transplantation.

AB - Mycobacterium tuberculosis infection is one of many opportunistic infections in renal transplant recipients, arising either from reactivation of latent infection or de novo infection, occasionally donor derived. M. tuberculosis hepatitis has never been reported in patients who have received alemtuzumab as part of their renal transplant management. We describe 2 patients who underwent deceased-donor renal transplantation following alemtuzumab induction therapy and presented with a febrile syndrome, subsequently diagnosed as tuberculous hepatitis, one with disseminated disease. Both responded well to treatment without significant side effects, resulting in excellent graft function. The importance of chemoprophylaxis should be emphasized to minimize the risk of developing active tuberculosis in patients with latent tuberculosis infection undergoing solid organ transplantation.

KW - Alemtuzumab

KW - Hepatitis

KW - Liver abscess

KW - Renal transplantation

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=84873415399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873415399&partnerID=8YFLogxK

U2 - 10.1111/tid.12048

DO - 10.1111/tid.12048

M3 - Article

C2 - 23278987

AN - SCOPUS:84873415399

VL - 15

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

SN - 1398-2273

IS - 1

ER -