Tuberculosis infection and disease in children living in households of Filipino patients with tuberculosis: A preliminary report

R. M.L. Salazar-Vergara, I. G. Sia, Thelma E. Tupasi, M. R. Alcañeses, R. B. Orillaza, V. Co, M. I.D. Quelapio, G. Beltran, J. D. Legaspi, M. P.C. Rostrata, M. E.B. Tecson, M. L.S.B. Corpuz

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

SETTING: DOTS Clinic with a DOTS-Plus pilot project for the management of multidrug-resistant tuberculosis (MDR-TB) in a high burden country. OBJECTIVE: To determine the prevalence of tuberculosis (TB) infection and disease among pediatric household contacts of patients with pulmonary TB (PTB). DESIGN: Cross-sectional study. METHODOLOGY: One hundred and fifty-three children aged 0-15 years in the households of 62 bacteriologically confirmed PTB patients, including 44 with MDR-TB, were studied. BCG scars were noted, and tuberculin skin test (TST), screening chest radiography, and sputum or gastric aspirate smear and culture for Mycobacterium tuberculosis in those with radiographic findings suggestive of PTB were done. RESULTS: For children in this study, the prevalences of latent TB infection (LTBI), radiographically diagnosed pulmonary TB, and bacillary pulmonary TB were 69.2%, 3.3%, and 0.65%, respectively. Only age ≥5 years was found to be a significant predictor of LTBI (OR 3.17, 95% CI 1.43-7.01). CONCLUSION: Contact investigation for active case-finding and early treatment of TB in children from households of patients with active PTB is essential for TB control. Further study on a more precise definition of TB infection and strategies for control in this population will be pursued.

Original languageEnglish (US)
Pages (from-to)S494-S500
JournalInternational Journal of Tuberculosis and Lung Disease
Volume7
Issue number12 SUPPL. 3
StatePublished - Dec 1 2003

Keywords

  • Contact tracing
  • Pediatric contact cases
  • Philippines
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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    Salazar-Vergara, R. M. L., Sia, I. G., Tupasi, T. E., Alcañeses, M. R., Orillaza, R. B., Co, V., Quelapio, M. I. D., Beltran, G., Legaspi, J. D., Rostrata, M. P. C., Tecson, M. E. B., & Corpuz, M. L. S. B. (2003). Tuberculosis infection and disease in children living in households of Filipino patients with tuberculosis: A preliminary report. International Journal of Tuberculosis and Lung Disease, 7(12 SUPPL. 3), S494-S500.