TY - JOUR
T1 - Troponin-Past, Present, and Future
AU - Jaffe, Allan S.
PY - 2012/6
Y1 - 2012/6
N2 - Cardiac troponin is the analyte of choice for the diagnosis of cardiac injury. It is highly specific for the heart and much more sensitive than prior biomarkers. Because of this increased sensitivity, clinicians have had to struggle with elevations in novel clinical situations. We have developed new understandings about coronary artery disease but also have begun to appreciate that many other entities as well can result in cardiac injury. As assays have increased in sensitivity over time, this trend has, if anything, accelerated. This review attempts to put the past, the present, and the future into a clinical perspective that will help clinicians.
AB - Cardiac troponin is the analyte of choice for the diagnosis of cardiac injury. It is highly specific for the heart and much more sensitive than prior biomarkers. Because of this increased sensitivity, clinicians have had to struggle with elevations in novel clinical situations. We have developed new understandings about coronary artery disease but also have begun to appreciate that many other entities as well can result in cardiac injury. As assays have increased in sensitivity over time, this trend has, if anything, accelerated. This review attempts to put the past, the present, and the future into a clinical perspective that will help clinicians.
UR - http://www.scopus.com/inward/record.url?scp=84860347595&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860347595&partnerID=8YFLogxK
U2 - 10.1016/j.cpcardiol.2012.02.002
DO - 10.1016/j.cpcardiol.2012.02.002
M3 - Article
C2 - 22548763
AN - SCOPUS:84860347595
SN - 0146-2806
VL - 37
SP - 209
EP - 228
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
IS - 6
ER -