TY - JOUR
T1 - Trisomy 15, sex chromosome loss, and hematological malignancy
AU - Baumgartner, Brian J.
AU - Shurafa, Muhammad
AU - Terebelo, Howard
AU - Tapazoglou, Efstathios
AU - Van Dyke, Daniel L.
PY - 2000/3
Y1 - 2000/3
N2 - We report 6 patients with myelodysplasia who, on routine cytogenetic studies, demonstrated trisomy 15. Four of these also had sex chromosome loss. A review of the literature revealed 6 other cases of trisomy 15 with sex chromosome loss and 22 cases of trisomy 15 as the sole chromosomal abnormality. All cases had hematologic malignancy or myelodysplasia. Trisomy 15 is uncommon but tends to be associated with myelodysplasia in older subjects, and with sex chromosome loss in about one third of cases. (C) Elsevier Science Inc., 2000.
AB - We report 6 patients with myelodysplasia who, on routine cytogenetic studies, demonstrated trisomy 15. Four of these also had sex chromosome loss. A review of the literature revealed 6 other cases of trisomy 15 with sex chromosome loss and 22 cases of trisomy 15 as the sole chromosomal abnormality. All cases had hematologic malignancy or myelodysplasia. Trisomy 15 is uncommon but tends to be associated with myelodysplasia in older subjects, and with sex chromosome loss in about one third of cases. (C) Elsevier Science Inc., 2000.
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U2 - 10.1016/S0165-4608(99)00163-6
DO - 10.1016/S0165-4608(99)00163-6
M3 - Article
C2 - 10704683
AN - SCOPUS:0034004431
SN - 0165-4608
VL - 117
SP - 132
EP - 135
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -