Trisomy 15, sex chromosome loss, and hematological malignancy

Brian J. Baumgartner, Muhammad Shurafa, Howard Terebelo, Efstathios Tapazoglou, Daniel L. Van Dyke

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We report 6 patients with myelodysplasia who, on routine cytogenetic studies, demonstrated trisomy 15. Four of these also had sex chromosome loss. A review of the literature revealed 6 other cases of trisomy 15 with sex chromosome loss and 22 cases of trisomy 15 as the sole chromosomal abnormality. All cases had hematologic malignancy or myelodysplasia. Trisomy 15 is uncommon but tends to be associated with myelodysplasia in older subjects, and with sex chromosome loss in about one third of cases. (C) Elsevier Science Inc., 2000.

Original languageEnglish (US)
Pages (from-to)132-135
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume117
Issue number2
DOIs
StatePublished - Mar 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Baumgartner, B. J., Shurafa, M., Terebelo, H., Tapazoglou, E., & Van Dyke, D. L. (2000). Trisomy 15, sex chromosome loss, and hematological malignancy. Cancer Genetics and Cytogenetics, 117(2), 132-135. https://doi.org/10.1016/S0165-4608(99)00163-6