Trinucleotide repeat polymorphism at five disease loci in mixed Hungarian population

Péter Gyürüs, János Molnár, Béla Melegh, Gábor Tóth, Eva Morava-Kozicz, György Kosztolányi, Károly Méhes

Research output: Contribution to journalArticle

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Abstract

In apparently healthy, unrelated Hungarians we examined triplet repeat length polymorphism at Huntington disease (HD), spinal and bulbar muscular atrophy (SBMA), spinocerebellar ataxia type 1 (SCA-1), dentatorubral- pallidoluysian atrophy (DRPLA), and myotonic dystrophy (MD) loci. The distribution of alleles of the SCA-1 locus was markedly different compared with Asians and Caucasian samples examined by Watkins WS, Bamshad M, and Jorde LB [1995: Hum Mol Genet 4:1485-1491]. The unimodal distribution of peaks was shifted towards the shorter repeats on the average with 4-5 repeats. Alleles under 21 repeats at the SBMA locus were significantly less frequent in Hungarians than in Asians and Caucasians. We also found significant difference in the distribution of DRPLA allele size at repeat length over 15 repeats; these alleles were less frequent in Hungarians compared with Asians and Caucasians. No significant differences were found in alleles at the MD and also at the HI) loci compared with the other groups. These findings suggest that these trinucleotide sites in combination with other markers are particularly useful for determination of the genetic origin of a population, if they can be compared with similar subset of data of other populations. The present results could not confirm the large genetic distance between Hungarian and Oriental races and the relatively short distance between Hungarian and other European populations suggested in earlier reports [Czeizel A, Benkmann H-G, Goedde HW, editors. 1991: Genetics of the Hungarian population. Budapest: Akademiai Kiado. p 82-334].

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalAmerican Journal of Medical Genetics
Volume87
Issue number3
DOIs
StatePublished - Nov 26 1999
Externally publishedYes

Fingerprint

Trinucleotide Repeats
Alleles
Progressive Myoclonic Epilepsy
Atrophic Muscular Disorders
Spinocerebellar Ataxias
Myotonic Dystrophy
Population
Viverridae
Huntington Disease
Population Genetics

Keywords

  • Disease loci
  • Genetic lineage
  • Population genetics
  • Short tandem repeat polymorphism

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Trinucleotide repeat polymorphism at five disease loci in mixed Hungarian population. / Gyürüs, Péter; Molnár, János; Melegh, Béla; Tóth, Gábor; Morava-Kozicz, Eva; Kosztolányi, György; Méhes, Károly.

In: American Journal of Medical Genetics, Vol. 87, No. 3, 26.11.1999, p. 245-250.

Research output: Contribution to journalArticle

Gyürüs, Péter ; Molnár, János ; Melegh, Béla ; Tóth, Gábor ; Morava-Kozicz, Eva ; Kosztolányi, György ; Méhes, Károly. / Trinucleotide repeat polymorphism at five disease loci in mixed Hungarian population. In: American Journal of Medical Genetics. 1999 ; Vol. 87, No. 3. pp. 245-250.
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AU - Gyürüs, Péter

AU - Molnár, János

AU - Melegh, Béla

AU - Tóth, Gábor

AU - Morava-Kozicz, Eva

AU - Kosztolányi, György

AU - Méhes, Károly

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N2 - In apparently healthy, unrelated Hungarians we examined triplet repeat length polymorphism at Huntington disease (HD), spinal and bulbar muscular atrophy (SBMA), spinocerebellar ataxia type 1 (SCA-1), dentatorubral- pallidoluysian atrophy (DRPLA), and myotonic dystrophy (MD) loci. The distribution of alleles of the SCA-1 locus was markedly different compared with Asians and Caucasian samples examined by Watkins WS, Bamshad M, and Jorde LB [1995: Hum Mol Genet 4:1485-1491]. The unimodal distribution of peaks was shifted towards the shorter repeats on the average with 4-5 repeats. Alleles under 21 repeats at the SBMA locus were significantly less frequent in Hungarians than in Asians and Caucasians. We also found significant difference in the distribution of DRPLA allele size at repeat length over 15 repeats; these alleles were less frequent in Hungarians compared with Asians and Caucasians. No significant differences were found in alleles at the MD and also at the HI) loci compared with the other groups. These findings suggest that these trinucleotide sites in combination with other markers are particularly useful for determination of the genetic origin of a population, if they can be compared with similar subset of data of other populations. The present results could not confirm the large genetic distance between Hungarian and Oriental races and the relatively short distance between Hungarian and other European populations suggested in earlier reports [Czeizel A, Benkmann H-G, Goedde HW, editors. 1991: Genetics of the Hungarian population. Budapest: Akademiai Kiado. p 82-334].

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