Trichinella spiralis

Role of non-H-2 genes in resistance to primary infection in mice

Donald L. Wassom, Bradford O. Brooks, Raymond H. Cypess, Chella S. David

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Two strains of mice which share identical H-2 genes but differ in their genetic backgrounds were compared for their ability to resist infection with Trichinella spiralis. The two strains of mice, C3HeB/FeJ and AKR/J, share the H-2k haplotype which is associated with susceptibility to primary infection with T. spiralis in H-2 congenic strains of mice. AKR/J mice, infected with 150 infective muscle larvae, harbored significantly fewer muscle larvae 30 days postinfection than did mice of the strain C3HeB/FeJ. Approximately equal numbers of worms establish in the small intestine of AKR and C3H mice, but the AKR mice expelled adult worms from the gut more rapidly than did mice of the C3H strain. By Day 9 postinfection, 50% of the worms had been expelled by the AKR mice whereas expulsion of worms from C3H mice was delayed beyond Day 9 and occurred primarily between Days 10 and 12. Over this same experimental period (Days 6-12), fecundity of female worms from AKR mice, measured as the mean newborn larvae/female/hour, was approximately one-half that of worms taken from C3H mice. These results support the conclusion that genes outside of the mouse H-2 complex regulate expulsion of adult worms from the gut. These background genes also markedly influence the fecundity of female worms.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalExperimental Parasitology
Volume55
Issue number2
DOIs
StatePublished - 1983

Fingerprint

Inbred AKR Mouse
Trichinella spiralis
Inbred C3H Mouse
Larva
Infection
Genes
Fertility
Congenic Mice
Muscles
Haplotypes
Small Intestine

Keywords

  • Genetic control
  • H-2-linked genes
  • Immune response
  • Mice
  • Nematode
  • parasitic
  • Trichinella spiralis

ASJC Scopus subject areas

  • Immunology
  • Parasitology
  • Infectious Diseases

Cite this

Trichinella spiralis : Role of non-H-2 genes in resistance to primary infection in mice. / Wassom, Donald L.; Brooks, Bradford O.; Cypess, Raymond H.; David, Chella S.

In: Experimental Parasitology, Vol. 55, No. 2, 1983, p. 153-158.

Research output: Contribution to journalArticle

Wassom, Donald L. ; Brooks, Bradford O. ; Cypess, Raymond H. ; David, Chella S. / Trichinella spiralis : Role of non-H-2 genes in resistance to primary infection in mice. In: Experimental Parasitology. 1983 ; Vol. 55, No. 2. pp. 153-158.
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