TY - JOUR
T1 - Triamterene crystalline nephropathy
AU - Nasr, Samih H.
AU - Milliner, Dawn S.
AU - Wooldridge, Thomas D.
AU - Sethi, Sanjeev
PY - 2014/1
Y1 - 2014/1
N2 - Medications can cause a tubulointerstitial insult leading to acute kidney injury through multiple mechanisms. Acute tubular injury, a dose-dependent process, occurs due to direct toxicity on tubular cells. Acute interstitial nephritis characterized by interstitial inflammation and tubulitis develops from drugs that incite an allergic reaction. Other less common mechanisms include osmotic nephrosis and crystalline nephropathy. The latter complication is rare but has been associated with several drugs, such as sulfadiazine, indinavir, methotrexate, and ciprofloxacin. Triamterene crystalline nephropathy has been reported only rarely, and its histologic characteristics are not well characterized. We report 2 cases of triamterene crystalline nephropathy, one of which initially was misdiagnosed as 2,8-dihydroxyadenine crystalline nephropathy.
AB - Medications can cause a tubulointerstitial insult leading to acute kidney injury through multiple mechanisms. Acute tubular injury, a dose-dependent process, occurs due to direct toxicity on tubular cells. Acute interstitial nephritis characterized by interstitial inflammation and tubulitis develops from drugs that incite an allergic reaction. Other less common mechanisms include osmotic nephrosis and crystalline nephropathy. The latter complication is rare but has been associated with several drugs, such as sulfadiazine, indinavir, methotrexate, and ciprofloxacin. Triamterene crystalline nephropathy has been reported only rarely, and its histologic characteristics are not well characterized. We report 2 cases of triamterene crystalline nephropathy, one of which initially was misdiagnosed as 2,8-dihydroxyadenine crystalline nephropathy.
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U2 - 10.1053/j.ajkd.2013.06.023
DO - 10.1053/j.ajkd.2013.06.023
M3 - Article
C2 - 23958399
AN - SCOPUS:84896546336
SN - 0272-6386
VL - 63
SP - 148
EP - 152
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 1
ER -