Trial of a topically administered local anesthetic (EMLA cream) for pain relief during central venous port accesses in children with cancer

Angela W. Miser, T. Suan Goh, Ann Marie Dose, Judith R. O'Fallon, Robert D. Niedringhaus, Donna L. Betcher, Patricia Simmons, Darlene J. MacKellar, Marilyn Arnold, Charles Lawrence Loprinzi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Procedure-related pain is a significant problem for many children receiving cytotoxic chemotherapy. In an effort to lessen this toxicity, we studied the efficacy and safety of administering topical local anesthesia using EMLA cream in 47 evaluable children with cancer undergoing implanted central venous port injections. Children (< 21 years old) scheduled to undergo repeated venous access procedures were selected for study. A placebo-controlled, randomized, double-blind, crossover study design was utilized. Statistically significant decreases in pain intensity scores (P < 0.002) were recorded by both children and investigators during the use of EMLA cream as compared with placebo. There was a good correlation between pain scores recorded by both patients and health care providers using both visual analog scales and categorized pain measurement tools. The topical application of EMLA cream 5% provides highly effective superficial anesthesia, and promises to be extremely useful for pain relief during percutaneous access procedures in cancer patients.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalJournal of Pain and Symptom Management
Volume9
Issue number4
DOIs
StatePublished - 1994

Fingerprint

Local Anesthetics
Pain
Cross-Over Studies
Neoplasms
Placebos
Local Anesthesia
Pain Measurement
Visual Analog Scale
Double-Blind Method
Health Personnel
Patient Care
Anesthesia
Research Personnel
Safety
Drug Therapy
Injections
EMLA

Keywords

  • children
  • cytotoxic chemotherapy
  • EMLA cream
  • Procedure-related pain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Neurology
  • Nursing(all)

Cite this

Trial of a topically administered local anesthetic (EMLA cream) for pain relief during central venous port accesses in children with cancer. / Miser, Angela W.; Goh, T. Suan; Dose, Ann Marie; O'Fallon, Judith R.; Niedringhaus, Robert D.; Betcher, Donna L.; Simmons, Patricia; MacKellar, Darlene J.; Arnold, Marilyn; Loprinzi, Charles Lawrence.

In: Journal of Pain and Symptom Management, Vol. 9, No. 4, 1994, p. 259-264.

Research output: Contribution to journalArticle

Miser, Angela W. ; Goh, T. Suan ; Dose, Ann Marie ; O'Fallon, Judith R. ; Niedringhaus, Robert D. ; Betcher, Donna L. ; Simmons, Patricia ; MacKellar, Darlene J. ; Arnold, Marilyn ; Loprinzi, Charles Lawrence. / Trial of a topically administered local anesthetic (EMLA cream) for pain relief during central venous port accesses in children with cancer. In: Journal of Pain and Symptom Management. 1994 ; Vol. 9, No. 4. pp. 259-264.
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