Trial of a topically administered local anesthetic (EMLA cream) for pain relief during central venous port accesses in children with cancer

Angela W. Miser, T. Suan Goh, Ann Marie Dose, Judith R. O'Fallon, Robert D. Niedringhaus, Donna L. Betcher, Patricia Simmons, Darlene J. MacKellar, Marilyn Arnold, Charles L. Loprinzi

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Procedure-related pain is a significant problem for many children receiving cytotoxic chemotherapy. In an effort to lessen this toxicity, we studied the efficacy and safety of administering topical local anesthesia using EMLA cream in 47 evaluable children with cancer undergoing implanted central venous port injections. Children (< 21 years old) scheduled to undergo repeated venous access procedures were selected for study. A placebo-controlled, randomized, double-blind, crossover study design was utilized. Statistically significant decreases in pain intensity scores (P < 0.002) were recorded by both children and investigators during the use of EMLA cream as compared with placebo. There was a good correlation between pain scores recorded by both patients and health care providers using both visual analog scales and categorized pain measurement tools. The topical application of EMLA cream 5% provides highly effective superficial anesthesia, and promises to be extremely useful for pain relief during percutaneous access procedures in cancer patients.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalJournal of pain and symptom management
Volume9
Issue number4
DOIs
StatePublished - May 1994

Keywords

  • EMLA cream
  • Procedure-related pain
  • children
  • cytotoxic chemotherapy

ASJC Scopus subject areas

  • Nursing(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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