Trial design: Blood pressure control and weight gain prevention in prehypertensive and hypertensive smokers: The treatment and prevention study

Mark W. Vander Weg, Robert C. Klesges, Jon O. Ebbert, Ellen J. Lichty, Margaret DeBon, Frederick North, Darrell R. Schroeder, Patricia M. Dubbert

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: Cigarette smokers with elevated blood pressure (BP) are at substantially higher risk for cardiovascular events compared to normotensive smokers. Although smoking cessation should be a primary treatment goal for these patients, increases in body weight accompanying smoking abstinence may further increase BP. Intervention strategies that facilitate smoking cessation and modify adverse changes in body weight and BP are needed. Methods: We describe an ongoing multi-site, two-phase, five-year randomized clinical trial. Participants are cigarette smokers with Prehypertension or Stage I Hypertension. In the first phase, participants receive a smoking cessation intervention combining behavioral counseling and nicotine replacement in an open-label fashion. In the second phase, participants who successfully quit smoking are randomly assigned to one of three lifestyle interventions: 1) weight gain prevention, 2) blood pressure control, or 3) usual lifestyle. Participants are followed for one year to assess changes in blood pressure, body weight, dietary intake, and physical activity. Conclusions: Results from the proposed study will provide important insights into the efficacy of various approaches to lifestyle modification in smokers at increased risk for cardiovascular events.

Original languageEnglish (US)
Pages (from-to)281-292
Number of pages12
JournalContemporary Clinical Trials
Volume29
Issue number2
DOIs
StatePublished - Mar 1 2008

Keywords

  • Blood pressure
  • Body weight
  • Cardiovascular disease
  • Cigarette smoking
  • Hypertension
  • Lifestyle modification

ASJC Scopus subject areas

  • Pharmacology (medical)

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