Trends of blood-borne infectious diseases in a rural blood donation center of southeast gabon (Koula-moutou)

Cyrille Bisseye, Landry Erik Mombo, Stéphane Meyet Me Bie, Apollinaire Edou, Jean Marie Eko Mba, Jean Charles Etho-Mengue, Kévin Mbacky, Arnaud Mongo-Delis, Bertrand M’batchi, Bolni Nagalo

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Abstract

Introduction: blood-borne pathogens such as human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) viruses and Treponema pallidum remain a major public health problem in sub-Saharan Africa. The purpose of this study was to assess the frequency and clinical implications of HIV, HBV, HCV and Treponema pallidum markers in blood donors in a rural area of Southeast Gabon (Koula-Moutou) from 2012 to 2017. Methods: hepatitis B surface antigen (HBsAg), anti-HIV, anti-HCV and anti-Treponema pallidum antibodies were screened using rapid diagnostic tests (RDTs). Results: of a total of 5,706 blood donors, 1,054 (18.5%) were seropositive for at least one infectious marker and 59 (5.6%) had serologic evidence of multiple infections. The overall seroprevalence of HIV, HBsAg, HCV, and syphilis was 3.1%; 5.9%; 6.2% and 3.3%, respectively. HIV, syphilis and HCV distributions were associated with neither the sex nor the age of the donors. Only HBsAg seroprevalence was significantly higher in donors of the age group 26-35 years old compared to donors of the age group 36-45 years (OR = 1.43 (95% CI: 1.01-2.04), P = 0.045). There was a significant increase in the frequencies of HIV and syphilis and a regression of HBsAg and HCV among blood donors. Conclusion: this study presents the epidemiology of the main pathogens detected in blood donors in a rural area in Gabon. We found that the overall distribution of transfusion transmitted infectious diseases were lower than those observed in the general population but could be underestimated due to the use of RDTs in the screening process of the blood donations.

Original languageEnglish (US)
Article number81
JournalPan African Medical Journal
Volume31
DOIs
StatePublished - Jan 1 2018

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Gabon
Blood Donors
Communicable Diseases
HIV
Hepatitis B Surface Antigens
Treponema pallidum
Syphilis
Seroepidemiologic Studies
Tissue Donors
Routine Diagnostic Tests
Age Groups
Blood-Borne Pathogens
Africa South of the Sahara
Hepatitis C
Hepatitis B
Epidemiology
Public Health
Viruses
Antibodies
Infection

Keywords

  • Blood-borne pathogens
  • Gabon
  • Koula-moutou
  • Seroprevalence
  • Trends

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Trends of blood-borne infectious diseases in a rural blood donation center of southeast gabon (Koula-moutou). / Bisseye, Cyrille; Mombo, Landry Erik; Bie, Stéphane Meyet Me; Edou, Apollinaire; Mba, Jean Marie Eko; Etho-Mengue, Jean Charles; Mbacky, Kévin; Mongo-Delis, Arnaud; M’batchi, Bertrand; Nagalo, Bolni.

In: Pan African Medical Journal, Vol. 31, 81, 01.01.2018.

Research output: Contribution to journalArticle

Bisseye, C, Mombo, LE, Bie, SMM, Edou, A, Mba, JME, Etho-Mengue, JC, Mbacky, K, Mongo-Delis, A, M’batchi, B & Nagalo, B 2018, 'Trends of blood-borne infectious diseases in a rural blood donation center of southeast gabon (Koula-moutou)', Pan African Medical Journal, vol. 31, 81. https://doi.org/10.11604/pamj.2018.31.81.16331
Bisseye, Cyrille ; Mombo, Landry Erik ; Bie, Stéphane Meyet Me ; Edou, Apollinaire ; Mba, Jean Marie Eko ; Etho-Mengue, Jean Charles ; Mbacky, Kévin ; Mongo-Delis, Arnaud ; M’batchi, Bertrand ; Nagalo, Bolni. / Trends of blood-borne infectious diseases in a rural blood donation center of southeast gabon (Koula-moutou). In: Pan African Medical Journal. 2018 ; Vol. 31.
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abstract = "Introduction: blood-borne pathogens such as human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) viruses and Treponema pallidum remain a major public health problem in sub-Saharan Africa. The purpose of this study was to assess the frequency and clinical implications of HIV, HBV, HCV and Treponema pallidum markers in blood donors in a rural area of Southeast Gabon (Koula-Moutou) from 2012 to 2017. Methods: hepatitis B surface antigen (HBsAg), anti-HIV, anti-HCV and anti-Treponema pallidum antibodies were screened using rapid diagnostic tests (RDTs). Results: of a total of 5,706 blood donors, 1,054 (18.5{\%}) were seropositive for at least one infectious marker and 59 (5.6{\%}) had serologic evidence of multiple infections. The overall seroprevalence of HIV, HBsAg, HCV, and syphilis was 3.1{\%}; 5.9{\%}; 6.2{\%} and 3.3{\%}, respectively. HIV, syphilis and HCV distributions were associated with neither the sex nor the age of the donors. Only HBsAg seroprevalence was significantly higher in donors of the age group 26-35 years old compared to donors of the age group 36-45 years (OR = 1.43 (95{\%} CI: 1.01-2.04), P = 0.045). There was a significant increase in the frequencies of HIV and syphilis and a regression of HBsAg and HCV among blood donors. Conclusion: this study presents the epidemiology of the main pathogens detected in blood donors in a rural area in Gabon. We found that the overall distribution of transfusion transmitted infectious diseases were lower than those observed in the general population but could be underestimated due to the use of RDTs in the screening process of the blood donations.",
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AU - Bie, Stéphane Meyet Me

AU - Edou, Apollinaire

AU - Mba, Jean Marie Eko

AU - Etho-Mengue, Jean Charles

AU - Mbacky, Kévin

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AU - M’batchi, Bertrand

AU - Nagalo, Bolni

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N2 - Introduction: blood-borne pathogens such as human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) viruses and Treponema pallidum remain a major public health problem in sub-Saharan Africa. The purpose of this study was to assess the frequency and clinical implications of HIV, HBV, HCV and Treponema pallidum markers in blood donors in a rural area of Southeast Gabon (Koula-Moutou) from 2012 to 2017. Methods: hepatitis B surface antigen (HBsAg), anti-HIV, anti-HCV and anti-Treponema pallidum antibodies were screened using rapid diagnostic tests (RDTs). Results: of a total of 5,706 blood donors, 1,054 (18.5%) were seropositive for at least one infectious marker and 59 (5.6%) had serologic evidence of multiple infections. The overall seroprevalence of HIV, HBsAg, HCV, and syphilis was 3.1%; 5.9%; 6.2% and 3.3%, respectively. HIV, syphilis and HCV distributions were associated with neither the sex nor the age of the donors. Only HBsAg seroprevalence was significantly higher in donors of the age group 26-35 years old compared to donors of the age group 36-45 years (OR = 1.43 (95% CI: 1.01-2.04), P = 0.045). There was a significant increase in the frequencies of HIV and syphilis and a regression of HBsAg and HCV among blood donors. Conclusion: this study presents the epidemiology of the main pathogens detected in blood donors in a rural area in Gabon. We found that the overall distribution of transfusion transmitted infectious diseases were lower than those observed in the general population but could be underestimated due to the use of RDTs in the screening process of the blood donations.

AB - Introduction: blood-borne pathogens such as human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) viruses and Treponema pallidum remain a major public health problem in sub-Saharan Africa. The purpose of this study was to assess the frequency and clinical implications of HIV, HBV, HCV and Treponema pallidum markers in blood donors in a rural area of Southeast Gabon (Koula-Moutou) from 2012 to 2017. Methods: hepatitis B surface antigen (HBsAg), anti-HIV, anti-HCV and anti-Treponema pallidum antibodies were screened using rapid diagnostic tests (RDTs). Results: of a total of 5,706 blood donors, 1,054 (18.5%) were seropositive for at least one infectious marker and 59 (5.6%) had serologic evidence of multiple infections. The overall seroprevalence of HIV, HBsAg, HCV, and syphilis was 3.1%; 5.9%; 6.2% and 3.3%, respectively. HIV, syphilis and HCV distributions were associated with neither the sex nor the age of the donors. Only HBsAg seroprevalence was significantly higher in donors of the age group 26-35 years old compared to donors of the age group 36-45 years (OR = 1.43 (95% CI: 1.01-2.04), P = 0.045). There was a significant increase in the frequencies of HIV and syphilis and a regression of HBsAg and HCV among blood donors. Conclusion: this study presents the epidemiology of the main pathogens detected in blood donors in a rural area in Gabon. We found that the overall distribution of transfusion transmitted infectious diseases were lower than those observed in the general population but could be underestimated due to the use of RDTs in the screening process of the blood donations.

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