TY - JOUR
T1 - Trends in invasive pneumococcal disease among older adults in Olmsted County, Minnesota
AU - Tsigrelis, Constantine
AU - Tleyjeh, Imad M.
AU - Lahr, Brian D.
AU - Nyre, Lisa M.
AU - Virk, Abinash
AU - Baddour, Larry M.
N1 - Funding Information:
This publication was also made possible by Grant Number 1 UL1 RR024150 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and the NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. Information on NCRR is available at http://www.ncrr.nih.gov . Information on Reengineering the Clinical Research Enterprise can be obtained from http://nihroadmap.nih.gov .
Funding Information:
Funding/Support This work was made possible by the Grant Number R01 AR30582 (Rochester Epidemiology Project) from the National Institutes of Health and the National Institute of Arthritis and Musculoskeletal and Skin Diseases. This work was supported in part by intramural research funding by the Small Grants Program and the Baddour Family Fund Research Grants Program from Mayo Clinic Rochester.
PY - 2009/9
Y1 - 2009/9
N2 - Objective: Following the introduction of a 7-valent pneumococcal conjugate vaccine (PCV-7) for children in early 2000 in the United States, a decrease in the incidence of invasive pneumococcal disease (IPD) was seen in adults, likely due to a herd effect. However, there have been recent increases in IPD in adults caused by Streptococcus pneumoniae serotypes not included in PCV-7, so called "replacement disease". We performed a population-based study to further investigate this emerging concern. Methods: Population-based incidence study in Olmsted County, Minnesota, United States, in adults aged ≥50 years. Results: From 1/1/1995 to 12/31/2007, 104 cases of IPD were identified in Olmsted County in adults aged ≥50 years. We found a 45% increase in the incidence rate of IPD from 2001-2003 (17.7 cases per 100,000 person-years) to 2004-2007 (32.1 cases per 100,000 person-years) (p = 0.029). From 2002-2004 to 2005-2007, the incidence rate of IPD caused by S. pneumoniae serotypes not included in PCV-7 increased from 9.2 to 32.8 cases per 100,000 person-years (p < 0.001). Conclusion: A recent increase in the incidence of IPD in adults aged ≥50 years was demonstrated in Olmsted County, Minnesota due to serotypes not found in PCV-7. These findings are unique and merit further investigation.
AB - Objective: Following the introduction of a 7-valent pneumococcal conjugate vaccine (PCV-7) for children in early 2000 in the United States, a decrease in the incidence of invasive pneumococcal disease (IPD) was seen in adults, likely due to a herd effect. However, there have been recent increases in IPD in adults caused by Streptococcus pneumoniae serotypes not included in PCV-7, so called "replacement disease". We performed a population-based study to further investigate this emerging concern. Methods: Population-based incidence study in Olmsted County, Minnesota, United States, in adults aged ≥50 years. Results: From 1/1/1995 to 12/31/2007, 104 cases of IPD were identified in Olmsted County in adults aged ≥50 years. We found a 45% increase in the incidence rate of IPD from 2001-2003 (17.7 cases per 100,000 person-years) to 2004-2007 (32.1 cases per 100,000 person-years) (p = 0.029). From 2002-2004 to 2005-2007, the incidence rate of IPD caused by S. pneumoniae serotypes not included in PCV-7 increased from 9.2 to 32.8 cases per 100,000 person-years (p < 0.001). Conclusion: A recent increase in the incidence of IPD in adults aged ≥50 years was demonstrated in Olmsted County, Minnesota due to serotypes not found in PCV-7. These findings are unique and merit further investigation.
KW - Aged
KW - Cohort studies
KW - Incidence
KW - Pneumococcal infections
KW - Streptococcus pneumoniae
UR - http://www.scopus.com/inward/record.url?scp=69749092181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69749092181&partnerID=8YFLogxK
U2 - 10.1016/j.jinf.2009.07.004
DO - 10.1016/j.jinf.2009.07.004
M3 - Article
C2 - 19635635
AN - SCOPUS:69749092181
SN - 0163-4453
VL - 59
SP - 188
EP - 193
JO - Journal of Infection
JF - Journal of Infection
IS - 3
ER -