Trends and Outcomes of Severe Sepsis in Patients on Maintenance Dialysis

Ankit Sakhuja, Rahul S. Nanchal, Shipra Gupta, Hatem Amer, Gagan Kumar, Robert C. Albright, Kianoush B. Kashani

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Though the incidence of severe sepsis is rising, there is a lack of contemporary information regarding the epidemiology and outcomes of severe sepsis in those on maintenance dialysis. The objectives of this study were to measure the incidence and outcomes of severe sepsis in those on maintenance dialysis. Methods: Using data from Nationwide Inpatient Sample database from 2005 to 2010, we included all hospitalizations of adults with severe sepsis based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. Those on maintenance dialysis were identified by ICD-9-CM codes. We calculated incidence of severe sepsis and mortality. We used logistic regression to assess independent effect of maintenance dialysis status on mortality. Results: Of the estimated 5,000,152 hospitalizations with severe sepsis, 322,734 (6.4%) were on maintenance dialysis. The unadjusted incidence of severe sepsis was 145.4 per 1,000 in those on maintenance dialysis in comparison to 3.5 per 1,000 in the general population. Mortality was higher in those with severe sepsis (30.3 vs. 26.2%; p <0.001). Maintenance dialysis is an independent predictor of death in those with severe sepsis (OR 1.26; 95% CI 1.23-1.29). Conclusions: Hospitalizations with severe sepsis are more prevalent and associated with poor outcomes in those on maintenance dialysis.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalAmerican Journal of Nephrology
DOIs
StateAccepted/In press - Mar 10 2016

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Keywords

  • End-stage renal disease
  • Mortality#
  • Sepsis

ASJC Scopus subject areas

  • Nephrology

Cite this

Sakhuja, A., Nanchal, R. S., Gupta, S., Amer, H., Kumar, G., Albright, R. C., & Kashani, K. B. (Accepted/In press). Trends and Outcomes of Severe Sepsis in Patients on Maintenance Dialysis. American Journal of Nephrology, 97-103. https://doi.org/10.1159/000444684