Trends affecting the future of vaccine development and delivery: The role of demographics, regulatory science, the anti-vaccine movement, and vaccinomics

Gregory A. Poland, Robert M. Jacobson, Inna G. Ovsyannikova

Research output: Contribution to journalArticle

72 Scopus citations


Important scientific, cultural, temporal, and secular issues impact the development of, and delivery of vaccines. In this paper we discuss the impact of demographics, regulatory science, the anti-vaccine movement, and finally the impact of the new biology and individualized medicine, which we call vaccinomics, on vaccine development and delivery. A description of the issues and how they have, are, or should be impacting vaccinology is provided, and hopefully will result in increased attention and discussion among vaccinologists. These issues have been under-valued, under-discussed, and in some cases, ignored. We hope that discussion of these issues will result in changes in how we develop, and how we communicate those developments, to the public.

Original languageEnglish (US)
Pages (from-to)3240-3244
Number of pages5
Issue number25-26
StatePublished - May 26 2009



  • Anti-vaccine
  • Gene polymorphisms
  • Randomized clinical trials
  • Vaccine
  • Vaccine future
  • Vaccinomics

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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