Trend toward improved day 100 and two-year survival following stem cell transplantation for AL: A comparison before and after 2006

M. A. Gertz; M. Q. Lacy; A. Dispenzieri; S. Kumar; S. R. Hayman; F. Buadi; D. Dingli; N. Leung; W. J. Hogan

doi:10.3109/13506129.2011.574354

Trend toward improved day 100 and two-year survival following stem cell transplantation for AL: A comparison before and after 2006

M. A. Gertz, M. Q. Lacy, A. Dispenzieri, S. Kumar, S. R. Hayman, F. Buadi, D. Dingli, N. Leung, W. J. Hogan

Hematology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We report 422 patients transplanted for light chain amyloidosis. Day-100 all-cause mortality has fallen from 12% prior to 1 January 2006 to 7% after 1 January 2006 (p = 0.09). Survival at 2 years has likewise improved from 78 to 82%. Serum troponin T and NT-proBNP were the only predictors of early mortality. Refined patient selection has improved the safety margin for patients undergoing high-dose therapy, and therapy-related mortality has been reduced by 40%.

Original language	English (US)
Pages (from-to)	137-138
Number of pages	2
Journal	Amyloid
Volume	18
Issue number	SUPPL. 1
DOIs	https://doi.org/10.3109/13506129.2011.574354
State	Published - Jun 2011

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.3109/13506129.2011.574354

Cite this

@article{a78a889a9a0b4d41a7f64c8ab04cd6c5,

title = "Trend toward improved day 100 and two-year survival following stem cell transplantation for AL: A comparison before and after 2006",

abstract = "We report 422 patients transplanted for light chain amyloidosis. Day-100 all-cause mortality has fallen from 12% prior to 1 January 2006 to 7% after 1 January 2006 (p = 0.09). Survival at 2 years has likewise improved from 78 to 82%. Serum troponin T and NT-proBNP were the only predictors of early mortality. Refined patient selection has improved the safety margin for patients undergoing high-dose therapy, and therapy-related mortality has been reduced by 40%.",

author = "Gertz, {M. A.} and Lacy, {M. Q.} and A. Dispenzieri and S. Kumar and Hayman, {S. R.} and F. Buadi and D. Dingli and N. Leung and Hogan, {W. J.}",

year = "2011",

month = jun,

doi = "10.3109/13506129.2011.574354",

language = "English (US)",

volume = "18",

pages = "137--138",

journal = "Amyloid",

issn = "1350-6129",

publisher = "Informa Healthcare",

number = "SUPPL. 1",

}

TY - JOUR

T1 - Trend toward improved day 100 and two-year survival following stem cell transplantation for AL

T2 - A comparison before and after 2006

AU - Gertz, M. A.

AU - Lacy, M. Q.

AU - Dispenzieri, A.

AU - Kumar, S.

AU - Hayman, S. R.

AU - Buadi, F.

AU - Dingli, D.

AU - Leung, N.

AU - Hogan, W. J.

PY - 2011/6

Y1 - 2011/6

N2 - We report 422 patients transplanted for light chain amyloidosis. Day-100 all-cause mortality has fallen from 12% prior to 1 January 2006 to 7% after 1 January 2006 (p = 0.09). Survival at 2 years has likewise improved from 78 to 82%. Serum troponin T and NT-proBNP were the only predictors of early mortality. Refined patient selection has improved the safety margin for patients undergoing high-dose therapy, and therapy-related mortality has been reduced by 40%.

AB - We report 422 patients transplanted for light chain amyloidosis. Day-100 all-cause mortality has fallen from 12% prior to 1 January 2006 to 7% after 1 January 2006 (p = 0.09). Survival at 2 years has likewise improved from 78 to 82%. Serum troponin T and NT-proBNP were the only predictors of early mortality. Refined patient selection has improved the safety margin for patients undergoing high-dose therapy, and therapy-related mortality has been reduced by 40%.

UR - http://www.scopus.com/inward/record.url?scp=79959968213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959968213&partnerID=8YFLogxK

U2 - 10.3109/13506129.2011.574354

DO - 10.3109/13506129.2011.574354

M3 - Article

AN - SCOPUS:79959968213

SN - 1350-6129

VL - 18

SP - 137

EP - 138

JO - Amyloid

JF - Amyloid

IS - SUPPL. 1

ER -

Trend toward improved day 100 and two-year survival following stem cell transplantation for AL: A comparison before and after 2006

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this