TREMs in Alzheimer's disease: Genetic and clinical investigations

Jia Cheng; Xiao Feng Guo; Tian Zhang; Li Zhong; Guo Jun Bu; Xiao Fen Chen

doi:10.1016/j.cca.2016.10.022

TREMs in Alzheimer's disease: Genetic and clinical investigations

Jia Cheng, Xiao Feng Guo, Tian Zhang, Li Zhong, Guo Jun Bu, Xiao Fen Chen

Neuroscience

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Triggering receptor expressed on myeloid cells (TREMs) receptors constitute a family modulators in human innate immunity system that encode by a gene cluster. Rare variants in TREM2 were reported to be associated with significant Alzheimer's disease (AD) risk. However, inconsistent results were also reported in some studies of Non-European descents. Recently, the other TREM family members are also considered to involve in AD and cerebrospinal fluid (CSF) soluble form of TREM2 (sTREM2) levels has also been associated with respond to progression of disease. In this review, we converged the data of genetic and clinical investigations to identify the clearer role of TREMs in AD. Here, comprehensively analyze of multidisciplinary fields highlights the contribution of TREMs locus to AD development.

Original language	English (US)
Pages (from-to)	88-95
Number of pages	8
Journal	Clinica Chimica Acta
Volume	463
DOIs	https://doi.org/10.1016/j.cca.2016.10.022
State	Published - Dec 1 2016

Keywords

Alzheimer's disease
Biomarker
Epigenetic
TREM2
TREML
sTREM2

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Biochemistry, medical

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10.1016/j.cca.2016.10.022

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title = "TREMs in Alzheimer's disease: Genetic and clinical investigations",

abstract = "Triggering receptor expressed on myeloid cells (TREMs) receptors constitute a family modulators in human innate immunity system that encode by a gene cluster. Rare variants in TREM2 were reported to be associated with significant Alzheimer's disease (AD) risk. However, inconsistent results were also reported in some studies of Non-European descents. Recently, the other TREM family members are also considered to involve in AD and cerebrospinal fluid (CSF) soluble form of TREM2 (sTREM2) levels has also been associated with respond to progression of disease. In this review, we converged the data of genetic and clinical investigations to identify the clearer role of TREMs in AD. Here, comprehensively analyze of multidisciplinary fields highlights the contribution of TREMs locus to AD development.",

keywords = "Alzheimer's disease, Biomarker, Epigenetic, TREM2, TREML, sTREM2",

author = "Jia Cheng and Guo, {Xiao Feng} and Tian Zhang and Li Zhong and Bu, {Guo Jun} and Chen, {Xiao Fen}",

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year = "2016",

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doi = "10.1016/j.cca.2016.10.022",

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T1 - TREMs in Alzheimer's disease

T2 - Genetic and clinical investigations

AU - Cheng, Jia

AU - Guo, Xiao Feng

AU - Zhang, Tian

AU - Zhong, Li

AU - Bu, Guo Jun

AU - Chen, Xiao Fen

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Triggering receptor expressed on myeloid cells (TREMs) receptors constitute a family modulators in human innate immunity system that encode by a gene cluster. Rare variants in TREM2 were reported to be associated with significant Alzheimer's disease (AD) risk. However, inconsistent results were also reported in some studies of Non-European descents. Recently, the other TREM family members are also considered to involve in AD and cerebrospinal fluid (CSF) soluble form of TREM2 (sTREM2) levels has also been associated with respond to progression of disease. In this review, we converged the data of genetic and clinical investigations to identify the clearer role of TREMs in AD. Here, comprehensively analyze of multidisciplinary fields highlights the contribution of TREMs locus to AD development.

AB - Triggering receptor expressed on myeloid cells (TREMs) receptors constitute a family modulators in human innate immunity system that encode by a gene cluster. Rare variants in TREM2 were reported to be associated with significant Alzheimer's disease (AD) risk. However, inconsistent results were also reported in some studies of Non-European descents. Recently, the other TREM family members are also considered to involve in AD and cerebrospinal fluid (CSF) soluble form of TREM2 (sTREM2) levels has also been associated with respond to progression of disease. In this review, we converged the data of genetic and clinical investigations to identify the clearer role of TREMs in AD. Here, comprehensively analyze of multidisciplinary fields highlights the contribution of TREMs locus to AD development.

KW - Alzheimer's disease

KW - Biomarker

KW - Epigenetic

KW - TREM2

KW - TREML

KW - sTREM2

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DO - 10.1016/j.cca.2016.10.022

M3 - Review article

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SN - 0009-8981

VL - 463

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EP - 95

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -

TREMs in Alzheimer's disease: Genetic and clinical investigations

Abstract

Keywords

ASJC Scopus subject areas

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