Treatment with basic fibroblastic growth factor following focal cerebral ischemia does not prevent neuronal injury

Hiroshi Tenjin, Robert E. Anderson, Fredric B. Meyer

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This experiment determined if postischemic administration of basic fibroblast growth factor (bFGF) would result in neovascularization to minimize neuronal injury following a focal cerebral ischemia insult. Fifty-eight Sprague-Dawley rats underwent middle cerebral artery (MCA) occlusion and were divided into three groups receiving either vehicle, serum, or 50 ng bFGF biweekly through an indwelling ventricular cannula. At variable time intervals, the animals underwent carbon black perfusion of capillary beds and histological staining for assessment of neuronal injury. Following MCA occlusion, there was a significant decrease in capillary bed density in peri-infarction cortex which normalized by two weeks. The number of alive neurons in the peri-infarction cortex was also significantly decreased compared to contralateral control cortex. The chronic administration of bFGF commencing two days after MCA occlusion did not result in either a significant increase in capillary bed density or the number of alive neurons in the peri-infarction cortex.

Original languageEnglish (US)
Pages (from-to)66-70
Number of pages5
JournalJournal of the Neurological Sciences
Volume128
Issue number1
DOIs
StatePublished - 1995

Fingerprint

Middle Cerebral Artery Infarction
Fibroblast Growth Factor 2
Brain Ischemia
Infarction
Intercellular Signaling Peptides and Proteins
Wounds and Injuries
Soot
Neurons
Sprague Dawley Rats
Perfusion
Staining and Labeling
Serum

Keywords

  • FGF
  • Capillary
  • Focal cerebral ischemia
  • Neovascularization
  • Neuronal injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Aging
  • Surgery
  • Developmental Neuroscience
  • Neuroscience(all)

Cite this

Treatment with basic fibroblastic growth factor following focal cerebral ischemia does not prevent neuronal injury. / Tenjin, Hiroshi; Anderson, Robert E.; Meyer, Fredric B.

In: Journal of the Neurological Sciences, Vol. 128, No. 1, 1995, p. 66-70.

Research output: Contribution to journalArticle

Tenjin, Hiroshi ; Anderson, Robert E. ; Meyer, Fredric B. / Treatment with basic fibroblastic growth factor following focal cerebral ischemia does not prevent neuronal injury. In: Journal of the Neurological Sciences. 1995 ; Vol. 128, No. 1. pp. 66-70.
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