Treatment Strategies and Clinical Trial Design in ADPKD

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

More frequent utilization and continuous improvement of imaging techniques has enhanced appreciation of the high phenotypic variability of autosomal dominant polycystic kidney disease, improved understanding of its natural history, and facilitated the observation of its structural progression. At the same time, identification of the PKD1 and PKD2 genes has provided clues to how the disease develops when they (genetic mechanisms) and their encoded proteins (molecular mechanisms) are disrupted. Interventions designed to rectify downstream effects of these disruptions have been examined in animal models, and some are currently tested in clinical trials. Efforts are underway to determine whether interventions capable to slow down, stop, or reverse structural progression of the disease will also prevent decline of renal function and improve clinically significant outcomes.

Original languageEnglish (US)
Pages (from-to)190-204
Number of pages15
JournalAdvances in Chronic Kidney Disease
Volume17
Issue number2
DOIs
StatePublished - Mar 2010

Keywords

  • ADPKD
  • Consortium for radiologic imaging study of PKD
  • Cyclic AMP
  • Mammalian target of rapamycin
  • Polycystic kidney disease
  • Somatostatin analogs
  • Vasopressin V2 receptor antagonist

ASJC Scopus subject areas

  • Nephrology

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