Abstract
We used three to six courses of 2-chlorodeoxyadenosine (2-CdA) (2-h infusion at 0.14mg/kg per day × 5 days) given over a period of 3-36 months to treat four patients with aggressive systemic mast cell disease (SMCD) that was resistant to interferon-alpha (IFN-α). Treatment with 2-CdA resulted in a major response in two patients and a good partial response in one other patient (75% overall response). Treatment was well tolerated and duration of remission in responding patients ranges from 2 months to 4+ years since the completion of treatment with 2-CdA.
Original language | English (US) |
---|---|
Pages (from-to) | 127-131 |
Number of pages | 5 |
Journal | Leukemia Research |
Volume | 28 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2004 |
Keywords
- 2-Chlorodeoxyadenosine
- Interferon-alpha
- Systemic mast cell disease
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research