Treatment of severe Evans syndrome with an allogeneic cord blood transplant

E. Raetz, P. G. Beatty, R. H. Adams

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Immunosuppressive therapy is commonly used in the management of autoimmune disorders. As marrow-derived lymphocytes appear to play a key role in these diseases, lymphoid ablation followed by replacement with autologous or allogeneic stem cells may be a therapeutic option. We report a 5-year-old boy with severe Evans syndrome which consists of immune thrombocytopenia and Coombs-positive hemolytic anemia. He was rendered into complete remission with marrow ablation followed by rescue with an HLA-identical sibling cord blood transplant. He unexpectedly died 9 months following transplant from acute hepatic failure of unknown etiology.

Original languageEnglish (US)
Pages (from-to)427-429
Number of pages3
JournalBone Marrow Transplantation
Volume20
Issue number5
DOIs
StatePublished - Sep 1 1997

Keywords

  • Autoimmune disease
  • Cord blood transplant
  • Evans syndrome

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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