Abstract
Immunosuppressive therapy is commonly used in the management of autoimmune disorders. As marrow-derived lymphocytes appear to play a key role in these diseases, lymphoid ablation followed by replacement with autologous or allogeneic stem cells may be a therapeutic option. We report a 5-year-old boy with severe Evans syndrome which consists of immune thrombocytopenia and Coombs-positive hemolytic anemia. He was rendered into complete remission with marrow ablation followed by rescue with an HLA-identical sibling cord blood transplant. He unexpectedly died 9 months following transplant from acute hepatic failure of unknown etiology.
Original language | English (US) |
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Pages (from-to) | 427-429 |
Number of pages | 3 |
Journal | Bone Marrow Transplantation |
Volume | 20 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1 1997 |
Keywords
- Autoimmune disease
- Cord blood transplant
- Evans syndrome
ASJC Scopus subject areas
- Hematology
- Transplantation