Treatment of Parkinson's disease: Focus on quality of life issues

Ryan J. Uitti

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The vast majority of Parkinson's disease (PD) treatment discussions focus on two areas: pharmacotherapy and surgery. Why? These treatments produce relatively easily measurable outcomes concerning traditional diagnostic criteria: motor rating scores and "on" times. However, despite the expanding number of drugs and surgery, there is dwindling incremental improvement from the best motor outcomes available even 40 years ago. Over the same time period, recognition of the clinical scope of this syndrome has expanded tremendously. Much of this scope impacts on quality of life and is treatable. Two arenas with great potential impact on quality of life are mental health and activity/exercise. Early in the course of PD, depression and expectations about impending demise impact significantly on the quality of life of patients. Initial responses to medical therapy may also dictate patients' expectations. Later, the two most devastating features may be motor instability/falls/injury and dementia. Mounting evidence for the benefits of treatment aimed at these arenas is accumulating and revolves around recognition and facilitating healthy routines that may mitigate future negative clinical phenomenon. Keys concerning mental health include education with realistic expectations and identification/treatment of mood and sleep disorders. Effective pro-active treatment regimens for instability and dementia include activity/exercise advocacy.

Original languageEnglish (US)
JournalParkinsonism and Related Disorders
Volume18
Issue numberSUPPL. 1
StatePublished - Jan 2012

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Parkinson Disease
Quality of Life
Dementia
Mental Health
Therapeutics
Exercise
Mood Disorders
Health Education
Depression
Drug Therapy
Wounds and Injuries
Pharmaceutical Preparations

Keywords

  • Parkinson's disease
  • Quality of life
  • Treatment

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Treatment of Parkinson's disease : Focus on quality of life issues. / Uitti, Ryan J.

In: Parkinsonism and Related Disorders, Vol. 18, No. SUPPL. 1, 01.2012.

Research output: Contribution to journalArticle

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