TY - JOUR
T1 - Treatment of limited-stage small-cell lung cancer with cyclophosphamide, doxorubicin, and vincristine with or without etoposide
T2 - A randomized trial of the north central cancer treatment group
AU - Jett, James R.
AU - Everson, Lloyd
AU - Therneau, Terry M.
AU - Krook, James E.
AU - Dalton, Robert J.
AU - Marschke, Robert F.
AU - Veeder, Michael H.
AU - Brunk, S. Fred
AU - Mailliard, James A.
AU - Twito, Donald I.
AU - Earle, John D.
AU - Anderson, Richard T.
PY - 1990
Y1 - 1990
N2 - In this randomized study involving patients with limited-stage small-cell lung cancer (LD-SCC), we compared treatment with either cyclophosphamide, doxorubicin, and vincristine (CAV) or CAV plus etoposide (CAVE). All patients received identical thoracic radiation consisting of 3,750 cGy in 15 fractions and prophylactic cranial radiation (3,000 cGy in 10 fractions). Among 231 evaluable patients, the two treatment arms were well matched with respect to sex, age, performance score, and presence or absence of heart disease. A major regression (REGR) was observed in 83% of all patients and a complete response (CR) in 60%. There was no difference in the response rate between the two treatment regimens. The median time to progression is 10.4 months (95% confidence interval [CI], 8.9 to 12 months) for CAVE versus 8.9 months (95% CI, 7.9 to 10.4 months) for CAV (P = .04). The median survival is 15.1 months (95% CI, 11.7 to 17.8 months) for CAVE versus 12.4 months (95% CI, 11 to 14.4 months) for CAV. This difference is not significantly different (P = .13). Toxicity was primarily myelosuppression and was significantly greater for the four-drug regimen. Fatal treatment-related toxicity was observed in two patients on the CAVE regimen and no treatment-related deaths were observed on the CAV treatment. In conclusion, the addition of etoposide to the CAV regimen resulted in increased toxicity but did not lead to a meaningful improvement in survival.
AB - In this randomized study involving patients with limited-stage small-cell lung cancer (LD-SCC), we compared treatment with either cyclophosphamide, doxorubicin, and vincristine (CAV) or CAV plus etoposide (CAVE). All patients received identical thoracic radiation consisting of 3,750 cGy in 15 fractions and prophylactic cranial radiation (3,000 cGy in 10 fractions). Among 231 evaluable patients, the two treatment arms were well matched with respect to sex, age, performance score, and presence or absence of heart disease. A major regression (REGR) was observed in 83% of all patients and a complete response (CR) in 60%. There was no difference in the response rate between the two treatment regimens. The median time to progression is 10.4 months (95% confidence interval [CI], 8.9 to 12 months) for CAVE versus 8.9 months (95% CI, 7.9 to 10.4 months) for CAV (P = .04). The median survival is 15.1 months (95% CI, 11.7 to 17.8 months) for CAVE versus 12.4 months (95% CI, 11 to 14.4 months) for CAV. This difference is not significantly different (P = .13). Toxicity was primarily myelosuppression and was significantly greater for the four-drug regimen. Fatal treatment-related toxicity was observed in two patients on the CAVE regimen and no treatment-related deaths were observed on the CAV treatment. In conclusion, the addition of etoposide to the CAV regimen resulted in increased toxicity but did not lead to a meaningful improvement in survival.
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M3 - Article
C2 - 2153193
AN - SCOPUS:0025141733
SN - 0732-183X
VL - 8
SP - 33
EP - 38
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 1
ER -