Treatment of Intractable Hiccup with Baclofen: Results of a Double‐Blind Randomized, Controlled, Cross‐over Study

Francisco C. Ramirez, David Y. Graham

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Four patients with intractable hiccup were treated In a double‐blind, randomized, placebo, cross‐over study with an analogue of μgm‐aminobutyric acid, Baclofen. There was a consistent and statistically significant (p= 0.03) improvement in hiccup severity with Baclofen, both subjectively (p= 0.03) and by hiccup‐free periods (p= 0.003). The actual frequency of hiccup was not significantly altered by the medication. We propose that the mechanical aspects of hiccup are reduced by Baclofen, leading to a perceptual blockage and a decrease in the reflex severity induced by the μgm‐aminobutyric acid analogue. We conclude that this medication may be useful for the treatment of intractable hiccup.

Original languageEnglish (US)
Pages (from-to)1789-1791
Number of pages3
JournalThe American Journal of Gastroenterology
Issue number12
StatePublished - Dec 1992


ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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