Four patients with intractable hiccup were treated In a double‐blind, randomized, placebo, cross‐over study with an analogue of μgm‐aminobutyric acid, Baclofen. There was a consistent and statistically significant (p= 0.03) improvement in hiccup severity with Baclofen, both subjectively (p= 0.03) and by hiccup‐free periods (p= 0.003). The actual frequency of hiccup was not significantly altered by the medication. We propose that the mechanical aspects of hiccup are reduced by Baclofen, leading to a perceptual blockage and a decrease in the reflex severity induced by the μgm‐aminobutyric acid analogue. We conclude that this medication may be useful for the treatment of intractable hiccup.
|Original language||English (US)|
|Number of pages||3|
|Journal||The American Journal of Gastroenterology|
|State||Published - Dec 1992|
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