Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation

Jacek Gronwald, Karen Glass, Barry Rosen, Beth Karlan, Nadine Tung, Susan L. Neuhausen, Pal Moller, Peter Ainsworth, Ping Sun, Steven A. Narod, Jan Lubinski, Joanne Kotsopoulos, Henry T. Lynch, Cezary Cybulski, Charmaine Kim-Sing, Susan Friedman, Leigha Senter, Jeffrey Weitzel, Christian Singer, Charis EngGillian Mitchell, Tomasz Huzarski, Jeanna McCuaig, Andrea Eisen, Dawna Gilchrist, Joanne L. Blum, Dana Zakalik, Tuya Pal, Mary Daly, Barbara Weber, Carrie Snyder, Taya Fallen, Albert Chudley, John Lunn, Talia Donenberg, Raluca N. Kurz, Howard Saal, Judy Garber, Gad Rennert, Kevin Sweet, Christine Rappaport, Edmond Lemire, Dominique Stoppa-Lyonnet, Olufunmilayo I. Olopade, Sofia Merajver, Louise Bordeleau, Carey A. Cullinane, Eitan Friedman, Wendy McKinnon, Marie Wood, Daniel Rayson, Wendy Meschino, Josephine Wagner Costalas, Robert E. Reilly, Susan Vadaparampil, Kenneth Offit, Noah Kauff, David Euhus, Ava Kwong, Claudine Isaacs, Fergus Couch, Siranoush Manoukian, Tomasz Byrski, Christine Elser, Seema Panchal, Susan Armel, Rochelle Demsky, Sonia Nanda, Kelly Metcalfe, Aletta Poll, William D. Foulkes, Andre Robidoux, Ellen Warner, Lovise Maehle, Gareth Evans, Barbara Pasini, Ophira Ginsburg, Stephanie Cohen, Anna Jakubowska, Janice Little

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objective To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Design A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. Setting Genetic clinics. Patient(s) Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire. Intervention(s) None. Main Outcome Measure(s) Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment. Result(s) There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer. Conclusion(s) Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.

Original languageEnglish (US)
Pages (from-to)781-785
Number of pages5
JournalFertility and sterility
Volume105
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • BRCA1
  • BRCA2
  • in vitro fertilization
  • infertility
  • ovarian cancer

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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    Gronwald, J., Glass, K., Rosen, B., Karlan, B., Tung, N., Neuhausen, S. L., Moller, P., Ainsworth, P., Sun, P., Narod, S. A., Lubinski, J., Kotsopoulos, J., Lynch, H. T., Cybulski, C., Kim-Sing, C., Friedman, S., Senter, L., Weitzel, J., Singer, C., ... Little, J. (2016). Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Fertility and sterility, 105(3), 781-785. https://doi.org/10.1016/j.fertnstert.2015.11.034