Treatment of Immunoglobulin Light Chain Amyloidosis Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Statement

Angela Dispenzieri, Francis Buadi, Shaji K Kumar, Craig B. Reeder, Taimur Sher, Martha Lacy, Robert A. Kyle, Joseph R Mikhael, Vivek Roy, Nelson Leung, Martha Grogan, Prashant Kapoor, John A. Lust, David M Dingli, Ronald S. Go, Yi Lisa Hwa, Suzanne R. Hayman, Rafael Fonseca, Sikander Ailawadhi, Peter Leif BergsagelAsher A Chanan Khan, S Vincent Rajkumar, Stephen J Russell, Alexander Keith Stewart, Steven R. Zeldenrust, Morie Gertz

Research output: Contribution to journalArticle

61 Scopus citations


Immunoglobulin light chain amyloidosis (AL amyloidosis) has an incidence of approximately 1 case per 100,000 person-years in Western countries. The rarity of the condition not only poses a challenge for making a prompt diagnosis but also makes evidenced decision making about treatment even more challenging. Physicians caring for patients with AL amyloidosis have been borrowing and customizing the therapies used for patients with multiple myeloma with varying degrees of success. One of the biggest failings in the science of the treatment of AL amyloidosis is the paucity of prospective trials, especially phase 3 trials. Herein, we present an extensive review of the literature with an aim of making recommendations in the context of the best evidence and expert opinion.

Original languageEnglish (US)
Pages (from-to)1054-1081
Number of pages28
JournalMayo Clinic Proceedings
Issue number8
StatePublished - Aug 1 2015


ASJC Scopus subject areas

  • Medicine(all)

Cite this