Treatment of Coagulopathy in Intracranial Hemorrhage

Maria I. Aguilar, William D. Freeman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Intracranial hemorrhage (ICH) complicated by coagulopathy is a medical emergency, which can delay neurosurgical intervention, lead to larger hematoma size, and increase mortality until the coagulopathy is corrected. Prompt recognition of coagulopathy during ICH is essential for correct, rapid treatment to reduce ongoing bleeding and improve survival. The proper treatment of a coagulopathic ICH patient is centered on rapid identification of the coagulopathic defect and correction of the underlying coagulopathy to stop acute bleeding. Patients with coagulopathic ICH require admission to a neuro-intensive unit care with management of airway, oxygenation, and systemic arterial and cerebral perfusion pressure; optimization of serum glucose; aggressive treatment of fever; and rehabilitation. Once the coagulopathic defect is reversed, some patients benefit from emergent neurosurgical intervention to prevent secondary brain injury from raised intracranial pressure, hydrocephalus, or mass effect. The management of ICH patients prescribed common antithrombotics such as aspirin, clopidogrel, warfarin, or heparin, as well as thrombolytic agents such as tissue plasminogen activator, is the focus of this review.

Original languageEnglish (US)
Pages (from-to)113-128
Number of pages16
JournalCurrent Treatment Options in Neurology
Volume12
Issue number2
DOIs
StatePublished - Mar 2010

Fingerprint

Intracranial Hemorrhages
clopidogrel
Cerebrovascular Circulation
Hemorrhage
Therapeutics
Airway Management
Fibrinolytic Agents
Intracranial Pressure
Tissue Plasminogen Activator
Warfarin
Hydrocephalus
Hematoma
Brain Injuries
Aspirin
Intensive Care Units
Heparin
Emergencies
Fever
Rehabilitation
Glucose

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Treatment of Coagulopathy in Intracranial Hemorrhage. / Aguilar, Maria I.; Freeman, William D.

In: Current Treatment Options in Neurology, Vol. 12, No. 2, 03.2010, p. 113-128.

Research output: Contribution to journalArticle

Aguilar, Maria I. ; Freeman, William D. / Treatment of Coagulopathy in Intracranial Hemorrhage. In: Current Treatment Options in Neurology. 2010 ; Vol. 12, No. 2. pp. 113-128.
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