Treatment of chronic migraine

Hans Christoph Diener, Dagny Holle, David Dodick

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Chronic migraine is defined in different ways. The most commonly used definition is headache on more than 15 days per month in patients with migraine. Chronic migraine is difficult to treat and requires a multidisciplinary approach. Only two pharmacological treatments have been shown to be effective in placebo-controlled randomized trials: topiramate and local injection of botulinum toxin. Both therapies are effective in patients with chronic migraine with and without medication overuse. Many other substances have been investigated in chronic daily headache. All trials were underpowered and, therefore, recommendations concerning possible efficacy are not possible.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalCurrent pain and headache reports
Issue number1
StatePublished - Feb 2011


  • Botulinum toxin
  • Chronic migraine
  • Topiramate
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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