Treatment of Abulia with Carbidopa/Levodopa

Daniel Drubach, Gabriel Zeilig, Julio Perez, Ligia Peralta, Michael Makley

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Abulia is a clinical syndrome manifested by lack of spontaneity of action and speech, deficiency in initiation, apathy, inertia, mental and motor slowness, reduction in excur sion of motion, poor attention, and easy distractibility. Abulia has been conceptualized as laying in a continuum of motivational and emotional deficit in which apathy is at one extreme and akinetic mutism at the other, more severe extreme. Lesions in the frontal lobes have been most often implicated in the causality of abulia, but other areas of involvement have also been described. Some authors have reported the beneficial effect of dopaminergic agents in the treatment of abulia and other related disorders. We report on four patients with various disorders of the CNS and abulic symptoms who had a ben eficial response to administration of a carbidopa/levodopa (Sinemet) compound many months after the CNS insult responsible for the symptoms. We hypothesize that lev odopa may be beneficial in the treatment of abulia by increasing the availability of dopamine to the prefrontal cortex or related areas in the brain.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalNeurorehabilitation and Neural Repair
Volume9
Issue number3
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Apathy
Akinetic Mutism
Dopamine Agents
Frontal Lobe
Prefrontal Cortex
Causality
Dopamine
Brain
Therapeutics
levodopa drug combination carbidopa

Keywords

  • Abulia
  • Brain injury
  • Levodopa
  • Prefrontal cortex

ASJC Scopus subject areas

  • Rehabilitation
  • Neurology
  • Clinical Neurology

Cite this

Treatment of Abulia with Carbidopa/Levodopa. / Drubach, Daniel; Zeilig, Gabriel; Perez, Julio; Peralta, Ligia; Makley, Michael.

In: Neurorehabilitation and Neural Repair, Vol. 9, No. 3, 01.01.1995, p. 151-155.

Research output: Contribution to journalArticle

Drubach, Daniel ; Zeilig, Gabriel ; Perez, Julio ; Peralta, Ligia ; Makley, Michael. / Treatment of Abulia with Carbidopa/Levodopa. In: Neurorehabilitation and Neural Repair. 1995 ; Vol. 9, No. 3. pp. 151-155.
@article{c29e4d0b4b6449f2a9fb5862541ff664,
title = "Treatment of Abulia with Carbidopa/Levodopa",
abstract = "Abulia is a clinical syndrome manifested by lack of spontaneity of action and speech, deficiency in initiation, apathy, inertia, mental and motor slowness, reduction in excur sion of motion, poor attention, and easy distractibility. Abulia has been conceptualized as laying in a continuum of motivational and emotional deficit in which apathy is at one extreme and akinetic mutism at the other, more severe extreme. Lesions in the frontal lobes have been most often implicated in the causality of abulia, but other areas of involvement have also been described. Some authors have reported the beneficial effect of dopaminergic agents in the treatment of abulia and other related disorders. We report on four patients with various disorders of the CNS and abulic symptoms who had a ben eficial response to administration of a carbidopa/levodopa (Sinemet) compound many months after the CNS insult responsible for the symptoms. We hypothesize that lev odopa may be beneficial in the treatment of abulia by increasing the availability of dopamine to the prefrontal cortex or related areas in the brain.",
keywords = "Abulia, Brain injury, Levodopa, Prefrontal cortex",
author = "Daniel Drubach and Gabriel Zeilig and Julio Perez and Ligia Peralta and Michael Makley",
year = "1995",
month = "1",
day = "1",
doi = "10.1177/154596839500900303",
language = "English (US)",
volume = "9",
pages = "151--155",
journal = "Neurorehabilitation and Neural Repair",
issn = "1545-9683",
publisher = "SAGE Publications Inc.",
number = "3",

}

TY - JOUR

T1 - Treatment of Abulia with Carbidopa/Levodopa

AU - Drubach, Daniel

AU - Zeilig, Gabriel

AU - Perez, Julio

AU - Peralta, Ligia

AU - Makley, Michael

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Abulia is a clinical syndrome manifested by lack of spontaneity of action and speech, deficiency in initiation, apathy, inertia, mental and motor slowness, reduction in excur sion of motion, poor attention, and easy distractibility. Abulia has been conceptualized as laying in a continuum of motivational and emotional deficit in which apathy is at one extreme and akinetic mutism at the other, more severe extreme. Lesions in the frontal lobes have been most often implicated in the causality of abulia, but other areas of involvement have also been described. Some authors have reported the beneficial effect of dopaminergic agents in the treatment of abulia and other related disorders. We report on four patients with various disorders of the CNS and abulic symptoms who had a ben eficial response to administration of a carbidopa/levodopa (Sinemet) compound many months after the CNS insult responsible for the symptoms. We hypothesize that lev odopa may be beneficial in the treatment of abulia by increasing the availability of dopamine to the prefrontal cortex or related areas in the brain.

AB - Abulia is a clinical syndrome manifested by lack of spontaneity of action and speech, deficiency in initiation, apathy, inertia, mental and motor slowness, reduction in excur sion of motion, poor attention, and easy distractibility. Abulia has been conceptualized as laying in a continuum of motivational and emotional deficit in which apathy is at one extreme and akinetic mutism at the other, more severe extreme. Lesions in the frontal lobes have been most often implicated in the causality of abulia, but other areas of involvement have also been described. Some authors have reported the beneficial effect of dopaminergic agents in the treatment of abulia and other related disorders. We report on four patients with various disorders of the CNS and abulic symptoms who had a ben eficial response to administration of a carbidopa/levodopa (Sinemet) compound many months after the CNS insult responsible for the symptoms. We hypothesize that lev odopa may be beneficial in the treatment of abulia by increasing the availability of dopamine to the prefrontal cortex or related areas in the brain.

KW - Abulia

KW - Brain injury

KW - Levodopa

KW - Prefrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=84970348533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84970348533&partnerID=8YFLogxK

U2 - 10.1177/154596839500900303

DO - 10.1177/154596839500900303

M3 - Article

AN - SCOPUS:84970348533

VL - 9

SP - 151

EP - 155

JO - Neurorehabilitation and Neural Repair

JF - Neurorehabilitation and Neural Repair

SN - 1545-9683

IS - 3

ER -