Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis C

Lena Sibulesky, Justin H. Nguyen, Ricardo Paz-Fumagalli, C. Burcin Taner, Rolland C. Dickson

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Hepatitis C is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis C recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis C. However, pre- and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications.

Original languageEnglish (US)
Pages (from-to)5010-5013
Number of pages4
JournalWorld journal of gastroenterology
Volume15
Issue number40
DOIs
StatePublished - Dec 1 2009

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Keywords

  • Hypersplenism
  • Leukopenia
  • Liver transplant
  • Recurrent hepatitis C
  • Thrombocytopenia

ASJC Scopus subject areas

  • Gastroenterology

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