Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis C

Lena Sibulesky, Justin H Nguyen, Ricardo Paz-Fumagalli, C. Burcin Taner, Rolland Dickson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Hepatitis C is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis C recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis C. However, pre- and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications.

Original languageEnglish (US)
Pages (from-to)5010-5013
Number of pages4
JournalWorld Journal of Gastroenterology
Volume15
Issue number40
DOIs
StatePublished - 2009

Fingerprint

Hypersplenism
Hepatitis C
Liver
Transplants
Ribavirin
Graft Survival
Splenectomy
Therapeutics
Liver Transplantation
Interferons
Antiviral Agents
Transplant Recipients

Keywords

  • Hypersplenism
  • Leukopenia
  • Liver transplant
  • Recurrent hepatitis C
  • Thrombocytopenia

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis C. / Sibulesky, Lena; Nguyen, Justin H; Paz-Fumagalli, Ricardo; Taner, C. Burcin; Dickson, Rolland.

In: World Journal of Gastroenterology, Vol. 15, No. 40, 2009, p. 5010-5013.

Research output: Contribution to journalArticle

@article{dbc0604b8cb744938064fc2f7fcd9672,
title = "Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis C",
abstract = "Hepatitis C is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis C recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis C. However, pre- and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications.",
keywords = "Hypersplenism, Leukopenia, Liver transplant, Recurrent hepatitis C, Thrombocytopenia",
author = "Lena Sibulesky and Nguyen, {Justin H} and Ricardo Paz-Fumagalli and Taner, {C. Burcin} and Rolland Dickson",
year = "2009",
doi = "10.3748/wjg.15.5010",
language = "English (US)",
volume = "15",
pages = "5010--5013",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "40",

}

TY - JOUR

T1 - Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis C

AU - Sibulesky, Lena

AU - Nguyen, Justin H

AU - Paz-Fumagalli, Ricardo

AU - Taner, C. Burcin

AU - Dickson, Rolland

PY - 2009

Y1 - 2009

N2 - Hepatitis C is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis C recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis C. However, pre- and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications.

AB - Hepatitis C is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis C recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis C. However, pre- and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications.

KW - Hypersplenism

KW - Leukopenia

KW - Liver transplant

KW - Recurrent hepatitis C

KW - Thrombocytopenia

UR - http://www.scopus.com/inward/record.url?scp=73449122253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73449122253&partnerID=8YFLogxK

U2 - 10.3748/wjg.15.5010

DO - 10.3748/wjg.15.5010

M3 - Article

C2 - 19859992

AN - SCOPUS:73449122253

VL - 15

SP - 5010

EP - 5013

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 40

ER -