Treatment guidelines for preoperative radiation therapy for retroperitoneal sarcoma: Preliminary consensus of an international expert panel

Elizabeth H. Baldini, Dian Wang, Rick L M Haas, Charles N. Catton, Daniel J. Indelicato, David G. Kirsch, David Roberge, Kilian Salerno, Curtiland Deville, B. Ashleigh Guadagnolo, Brian O'Sullivan, Ivy A Petersen, Cecile Le Pechoux, Ross A. Abrams, Thomas F. Delaney

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Purpose Evidence for external beam radiation therapy (RT) as part of treatment for retroperitoneal sarcoma (RPS) is limited. Preoperative RT is the subject of a current randomized trial, but the results will not be available for many years. In the meantime, many practitioners use preoperative RT for RPS, and although this approach is used in practice, there are no radiation treatment guidelines. An international expert panel was convened to develop consensus treatment guidelines for preoperative RT for RPS. Methods and Materials An expert panel of 15 academic radiation oncologists who specialize in the treatment of sarcoma was assembled. A systematic review of reports related to RT for RPS, RT for extremity sarcoma, and RT-related toxicities for organs at risk was performed. Due to the paucity of high-quality published data on the subject of RT for RPS, consensus recommendations were based largely on expert opinion derived from clinical experience and extrapolation of relevant published reports. It is intended that these clinical practice guidelines be updated as pertinent data become available. Results Treatment guidelines for preoperative RT for RPS are presented. Conclusions An international panel of radiation oncologists who specialize in sarcoma reached consensus guidelines for preoperative RT for RPS. Many of the recommendations are based on expert opinion because of the absence of higher level evidence and, thus, are best regarded as preliminary. We emphasize that the role of preoperative RT for RPS has not been proven, and we await data from the European Organization for Research and Treatment of Cancer (EORTC) study of preoperative radiotherapy plus surgery versus surgery alone for patients with RPS. Further data are also anticipated pertaining to normal tissue dose constraints, particularly for bowel tolerance. Nonetheless, as we await these data, the guidelines herein can be used to establish treatment uniformity to aid future assessments of efficacy and toxicity.

Original languageEnglish (US)
Pages (from-to)602-612
Number of pages11
JournalInternational Journal of Radiation Oncology Biology Physics
Volume92
Issue number3
DOIs
StatePublished - Jul 1 2015

Fingerprint

Sarcoma
radiation therapy
Radiotherapy
cancer
Guidelines
Therapeutics
Expert Testimony
recommendations
surgery
toxicity
radiation
Organs at Risk
Practice Guidelines
organs
extrapolation
Extremities
Organizations
Radiation
dosage

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Treatment guidelines for preoperative radiation therapy for retroperitoneal sarcoma : Preliminary consensus of an international expert panel. / Baldini, Elizabeth H.; Wang, Dian; Haas, Rick L M; Catton, Charles N.; Indelicato, Daniel J.; Kirsch, David G.; Roberge, David; Salerno, Kilian; Deville, Curtiland; Guadagnolo, B. Ashleigh; O'Sullivan, Brian; Petersen, Ivy A; Le Pechoux, Cecile; Abrams, Ross A.; Delaney, Thomas F.

In: International Journal of Radiation Oncology Biology Physics, Vol. 92, No. 3, 01.07.2015, p. 602-612.

Research output: Contribution to journalArticle

Baldini, EH, Wang, D, Haas, RLM, Catton, CN, Indelicato, DJ, Kirsch, DG, Roberge, D, Salerno, K, Deville, C, Guadagnolo, BA, O'Sullivan, B, Petersen, IA, Le Pechoux, C, Abrams, RA & Delaney, TF 2015, 'Treatment guidelines for preoperative radiation therapy for retroperitoneal sarcoma: Preliminary consensus of an international expert panel', International Journal of Radiation Oncology Biology Physics, vol. 92, no. 3, pp. 602-612. https://doi.org/10.1016/j.ijrobp.2015.02.013
Baldini, Elizabeth H. ; Wang, Dian ; Haas, Rick L M ; Catton, Charles N. ; Indelicato, Daniel J. ; Kirsch, David G. ; Roberge, David ; Salerno, Kilian ; Deville, Curtiland ; Guadagnolo, B. Ashleigh ; O'Sullivan, Brian ; Petersen, Ivy A ; Le Pechoux, Cecile ; Abrams, Ross A. ; Delaney, Thomas F. / Treatment guidelines for preoperative radiation therapy for retroperitoneal sarcoma : Preliminary consensus of an international expert panel. In: International Journal of Radiation Oncology Biology Physics. 2015 ; Vol. 92, No. 3. pp. 602-612.
@article{026f31ada6be45eab8c99970a1efbc9c,
title = "Treatment guidelines for preoperative radiation therapy for retroperitoneal sarcoma: Preliminary consensus of an international expert panel",
abstract = "Purpose Evidence for external beam radiation therapy (RT) as part of treatment for retroperitoneal sarcoma (RPS) is limited. Preoperative RT is the subject of a current randomized trial, but the results will not be available for many years. In the meantime, many practitioners use preoperative RT for RPS, and although this approach is used in practice, there are no radiation treatment guidelines. An international expert panel was convened to develop consensus treatment guidelines for preoperative RT for RPS. Methods and Materials An expert panel of 15 academic radiation oncologists who specialize in the treatment of sarcoma was assembled. A systematic review of reports related to RT for RPS, RT for extremity sarcoma, and RT-related toxicities for organs at risk was performed. Due to the paucity of high-quality published data on the subject of RT for RPS, consensus recommendations were based largely on expert opinion derived from clinical experience and extrapolation of relevant published reports. It is intended that these clinical practice guidelines be updated as pertinent data become available. Results Treatment guidelines for preoperative RT for RPS are presented. Conclusions An international panel of radiation oncologists who specialize in sarcoma reached consensus guidelines for preoperative RT for RPS. Many of the recommendations are based on expert opinion because of the absence of higher level evidence and, thus, are best regarded as preliminary. We emphasize that the role of preoperative RT for RPS has not been proven, and we await data from the European Organization for Research and Treatment of Cancer (EORTC) study of preoperative radiotherapy plus surgery versus surgery alone for patients with RPS. Further data are also anticipated pertaining to normal tissue dose constraints, particularly for bowel tolerance. Nonetheless, as we await these data, the guidelines herein can be used to establish treatment uniformity to aid future assessments of efficacy and toxicity.",
author = "Baldini, {Elizabeth H.} and Dian Wang and Haas, {Rick L M} and Catton, {Charles N.} and Indelicato, {Daniel J.} and Kirsch, {David G.} and David Roberge and Kilian Salerno and Curtiland Deville and Guadagnolo, {B. Ashleigh} and Brian O'Sullivan and Petersen, {Ivy A} and {Le Pechoux}, Cecile and Abrams, {Ross A.} and Delaney, {Thomas F.}",
year = "2015",
month = "7",
day = "1",
doi = "10.1016/j.ijrobp.2015.02.013",
language = "English (US)",
volume = "92",
pages = "602--612",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Treatment guidelines for preoperative radiation therapy for retroperitoneal sarcoma

T2 - Preliminary consensus of an international expert panel

AU - Baldini, Elizabeth H.

AU - Wang, Dian

AU - Haas, Rick L M

AU - Catton, Charles N.

AU - Indelicato, Daniel J.

AU - Kirsch, David G.

AU - Roberge, David

AU - Salerno, Kilian

AU - Deville, Curtiland

AU - Guadagnolo, B. Ashleigh

AU - O'Sullivan, Brian

AU - Petersen, Ivy A

AU - Le Pechoux, Cecile

AU - Abrams, Ross A.

AU - Delaney, Thomas F.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Purpose Evidence for external beam radiation therapy (RT) as part of treatment for retroperitoneal sarcoma (RPS) is limited. Preoperative RT is the subject of a current randomized trial, but the results will not be available for many years. In the meantime, many practitioners use preoperative RT for RPS, and although this approach is used in practice, there are no radiation treatment guidelines. An international expert panel was convened to develop consensus treatment guidelines for preoperative RT for RPS. Methods and Materials An expert panel of 15 academic radiation oncologists who specialize in the treatment of sarcoma was assembled. A systematic review of reports related to RT for RPS, RT for extremity sarcoma, and RT-related toxicities for organs at risk was performed. Due to the paucity of high-quality published data on the subject of RT for RPS, consensus recommendations were based largely on expert opinion derived from clinical experience and extrapolation of relevant published reports. It is intended that these clinical practice guidelines be updated as pertinent data become available. Results Treatment guidelines for preoperative RT for RPS are presented. Conclusions An international panel of radiation oncologists who specialize in sarcoma reached consensus guidelines for preoperative RT for RPS. Many of the recommendations are based on expert opinion because of the absence of higher level evidence and, thus, are best regarded as preliminary. We emphasize that the role of preoperative RT for RPS has not been proven, and we await data from the European Organization for Research and Treatment of Cancer (EORTC) study of preoperative radiotherapy plus surgery versus surgery alone for patients with RPS. Further data are also anticipated pertaining to normal tissue dose constraints, particularly for bowel tolerance. Nonetheless, as we await these data, the guidelines herein can be used to establish treatment uniformity to aid future assessments of efficacy and toxicity.

AB - Purpose Evidence for external beam radiation therapy (RT) as part of treatment for retroperitoneal sarcoma (RPS) is limited. Preoperative RT is the subject of a current randomized trial, but the results will not be available for many years. In the meantime, many practitioners use preoperative RT for RPS, and although this approach is used in practice, there are no radiation treatment guidelines. An international expert panel was convened to develop consensus treatment guidelines for preoperative RT for RPS. Methods and Materials An expert panel of 15 academic radiation oncologists who specialize in the treatment of sarcoma was assembled. A systematic review of reports related to RT for RPS, RT for extremity sarcoma, and RT-related toxicities for organs at risk was performed. Due to the paucity of high-quality published data on the subject of RT for RPS, consensus recommendations were based largely on expert opinion derived from clinical experience and extrapolation of relevant published reports. It is intended that these clinical practice guidelines be updated as pertinent data become available. Results Treatment guidelines for preoperative RT for RPS are presented. Conclusions An international panel of radiation oncologists who specialize in sarcoma reached consensus guidelines for preoperative RT for RPS. Many of the recommendations are based on expert opinion because of the absence of higher level evidence and, thus, are best regarded as preliminary. We emphasize that the role of preoperative RT for RPS has not been proven, and we await data from the European Organization for Research and Treatment of Cancer (EORTC) study of preoperative radiotherapy plus surgery versus surgery alone for patients with RPS. Further data are also anticipated pertaining to normal tissue dose constraints, particularly for bowel tolerance. Nonetheless, as we await these data, the guidelines herein can be used to establish treatment uniformity to aid future assessments of efficacy and toxicity.

UR - http://www.scopus.com/inward/record.url?scp=84930599450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930599450&partnerID=8YFLogxK

U2 - 10.1016/j.ijrobp.2015.02.013

DO - 10.1016/j.ijrobp.2015.02.013

M3 - Article

C2 - 26068493

AN - SCOPUS:84930599450

VL - 92

SP - 602

EP - 612

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 3

ER -