Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats

Seong Min Ra, Hong Kim, Mi-Hyeon D Jang, Min Chul Shin, Taeck Hyun Lee, Baek Vin Lim, Chang Ju Kim, Ee Hwa Kim, Kyeong Mi Kim, Sung Soo Kim

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The effects of treadmill exercise and swimming on cell proliferation in the dentate gyrus and the involvement of opioid receptors were investigated via 5-bromo-2′-deoxyuridine (BrdU) immunohistochemistry. Sprague-Dawley rats of the running groups were made to run on treadmill for 30 min each day, while those of the swimming groups were made to swim for 5 min each day over 3 consecutive days. In addition, intensity-dependency of the effects of running and swimming on cell proliferation was investigated. The present results demonstrate that both treadmill running and swimming increase the number of BrdU-labeled cells in the dentate gyrus and these increasing effects are more potent in light intensity and 5 min swimming groups. Treatment with naloxone increases cell proliferation in the dentate gyrus in all groups, although this increase is statistically insignificant.

Original languageEnglish (US)
Pages (from-to)123-126
Number of pages4
JournalNeuroscience Letters
Volume333
Issue number2
DOIs
StatePublished - Nov 22 2002
Externally publishedYes

Fingerprint

Parahippocampal Gyrus
Dentate Gyrus
Running
Cell Proliferation
Deoxyuridine
Opioid Receptors
Bromodeoxyuridine
Naloxone
Sprague Dawley Rats
Immunohistochemistry
Light

Keywords

  • 5-Bromo-2′-deoxyuridine
  • Cell proliferation
  • Dentate gyrus
  • Naloxone
  • Swimming
  • Treadmill running

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats. / Ra, Seong Min; Kim, Hong; Jang, Mi-Hyeon D; Shin, Min Chul; Lee, Taeck Hyun; Lim, Baek Vin; Kim, Chang Ju; Kim, Ee Hwa; Kim, Kyeong Mi; Kim, Sung Soo.

In: Neuroscience Letters, Vol. 333, No. 2, 22.11.2002, p. 123-126.

Research output: Contribution to journalArticle

Ra, SM, Kim, H, Jang, M-HD, Shin, MC, Lee, TH, Lim, BV, Kim, CJ, Kim, EH, Kim, KM & Kim, SS 2002, 'Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats', Neuroscience Letters, vol. 333, no. 2, pp. 123-126. https://doi.org/10.1016/S0304-3940(02)01031-5
Ra, Seong Min ; Kim, Hong ; Jang, Mi-Hyeon D ; Shin, Min Chul ; Lee, Taeck Hyun ; Lim, Baek Vin ; Kim, Chang Ju ; Kim, Ee Hwa ; Kim, Kyeong Mi ; Kim, Sung Soo. / Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats. In: Neuroscience Letters. 2002 ; Vol. 333, No. 2. pp. 123-126.
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