Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats

Seong Min Ra; Hong Kim; Mi Hyeon Jang; Min Chul Shin; Taeck Hyun Lee; Baek Vin Lim; Chang Ju Kim; Ee Hwa Kim; Kyeong Mi Kim; Sung Soo Kim

doi:10.1016/S0304-3940(02)01031-5

Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats

Seong Min Ra, Hong Kim, Mi Hyeon Jang, Min Chul Shin, Taeck Hyun Lee, Baek Vin Lim, Chang Ju Kim, Ee Hwa Kim, Kyeong Mi Kim, Sung Soo Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

The effects of treadmill exercise and swimming on cell proliferation in the dentate gyrus and the involvement of opioid receptors were investigated via 5-bromo-2′-deoxyuridine (BrdU) immunohistochemistry. Sprague-Dawley rats of the running groups were made to run on treadmill for 30 min each day, while those of the swimming groups were made to swim for 5 min each day over 3 consecutive days. In addition, intensity-dependency of the effects of running and swimming on cell proliferation was investigated. The present results demonstrate that both treadmill running and swimming increase the number of BrdU-labeled cells in the dentate gyrus and these increasing effects are more potent in light intensity and 5 min swimming groups. Treatment with naloxone increases cell proliferation in the dentate gyrus in all groups, although this increase is statistically insignificant.

Original language	English (US)
Pages (from-to)	123-126
Number of pages	4
Journal	Neuroscience Letters
Volume	333
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(02)01031-5
State	Published - Nov 22 2002

Keywords

5-Bromo-2′-deoxyuridine
Cell proliferation
Dentate gyrus
Naloxone
Swimming
Treadmill running

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(02)01031-5

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title = "Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats",

abstract = "The effects of treadmill exercise and swimming on cell proliferation in the dentate gyrus and the involvement of opioid receptors were investigated via 5-bromo-2′-deoxyuridine (BrdU) immunohistochemistry. Sprague-Dawley rats of the running groups were made to run on treadmill for 30 min each day, while those of the swimming groups were made to swim for 5 min each day over 3 consecutive days. In addition, intensity-dependency of the effects of running and swimming on cell proliferation was investigated. The present results demonstrate that both treadmill running and swimming increase the number of BrdU-labeled cells in the dentate gyrus and these increasing effects are more potent in light intensity and 5 min swimming groups. Treatment with naloxone increases cell proliferation in the dentate gyrus in all groups, although this increase is statistically insignificant.",

keywords = "5-Bromo-2′-deoxyuridine, Cell proliferation, Dentate gyrus, Naloxone, Swimming, Treadmill running",

author = "Ra, {Seong Min} and Hong Kim and Jang, {Mi Hyeon} and Shin, {Min Chul} and Lee, {Taeck Hyun} and Lim, {Baek Vin} and Kim, {Chang Ju} and Kim, {Ee Hwa} and Kim, {Kyeong Mi} and Kim, {Sung Soo}",

note = "Funding Information: This work was supported by a grant from the Korea Research Foundation (KRF-99-042-i00015).",

year = "2002",

month = nov,

day = "22",

doi = "10.1016/S0304-3940(02)01031-5",

language = "English (US)",

volume = "333",

pages = "123--126",

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AU - Ra, Seong Min

AU - Kim, Hong

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lee, Taeck Hyun

AU - Lim, Baek Vin

AU - Kim, Chang Ju

AU - Kim, Ee Hwa

AU - Kim, Kyeong Mi

AU - Kim, Sung Soo

N1 - Funding Information: This work was supported by a grant from the Korea Research Foundation (KRF-99-042-i00015).

PY - 2002/11/22

Y1 - 2002/11/22

N2 - The effects of treadmill exercise and swimming on cell proliferation in the dentate gyrus and the involvement of opioid receptors were investigated via 5-bromo-2′-deoxyuridine (BrdU) immunohistochemistry. Sprague-Dawley rats of the running groups were made to run on treadmill for 30 min each day, while those of the swimming groups were made to swim for 5 min each day over 3 consecutive days. In addition, intensity-dependency of the effects of running and swimming on cell proliferation was investigated. The present results demonstrate that both treadmill running and swimming increase the number of BrdU-labeled cells in the dentate gyrus and these increasing effects are more potent in light intensity and 5 min swimming groups. Treatment with naloxone increases cell proliferation in the dentate gyrus in all groups, although this increase is statistically insignificant.

AB - The effects of treadmill exercise and swimming on cell proliferation in the dentate gyrus and the involvement of opioid receptors were investigated via 5-bromo-2′-deoxyuridine (BrdU) immunohistochemistry. Sprague-Dawley rats of the running groups were made to run on treadmill for 30 min each day, while those of the swimming groups were made to swim for 5 min each day over 3 consecutive days. In addition, intensity-dependency of the effects of running and swimming on cell proliferation was investigated. The present results demonstrate that both treadmill running and swimming increase the number of BrdU-labeled cells in the dentate gyrus and these increasing effects are more potent in light intensity and 5 min swimming groups. Treatment with naloxone increases cell proliferation in the dentate gyrus in all groups, although this increase is statistically insignificant.

KW - 5-Bromo-2′-deoxyuridine

KW - Cell proliferation

KW - Dentate gyrus

KW - Naloxone

KW - Swimming

KW - Treadmill running

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Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats

Abstract

Keywords

ASJC Scopus subject areas

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