Treadmill exercise suppresses NPY expression in the hypothalamus of food-deprived rats

Sung Soo Kim, Mal Soon Shin, Hong Kim, Eun Kyung Kim, Hee Hyuk Lee, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Chang Ju Kim

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2 Scopus citations

Abstract

Exercise has been known to potentially affect food intake. Neuropeptide Y (NPY) is a 36 amino acid peptide and concentrated in the hypothalamus which is an appetite-regulating area. NPY is known to stimulate appetite and decrease energy expenditure. In the present study, the effect of treadmill running on the NPY expression in the hypothalamus of food-deprived rats was investigated using immunohistochemistry. Enhanced NPY expression in the paraventricular nucleus (PVN) and arcuate nucleus (ARN) was observed in the food-deprived rats. Treadmill exercise suppressed the enhancement of NPY expression in the PVN and ARN following food deprivation, but this suppressive effect was not affected by exercise intensity. Based on the present results, it can be suggested that treadmill exercise is effective in limiting the enhancement of NPY expression following food-deprived conditions.

Original languageEnglish (US)
Pages (from-to)63-71
Number of pages9
JournalNeuroscience Research Communications
Volume34
Issue number2
DOIs
StatePublished - Mar 2004

Keywords

  • Arcuate nucleus
  • Neuropeptide Y
  • Paraventricular nucleus
  • Treadmill exercise

ASJC Scopus subject areas

  • Neuroscience(all)

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    Kim, S. S., Shin, M. S., Kim, H., Kim, E. K., Lee, H. H., Chang, H. K., Lee, T. H., Jang, M. H., Shin, M. C., Lim, B. V., & Kim, C. J. (2004). Treadmill exercise suppresses NPY expression in the hypothalamus of food-deprived rats. Neuroscience Research Communications, 34(2), 63-71. https://doi.org/10.1002/nrc.20001