Treadmill exercise suppresses NPY expression in the hypothalamus of food-deprived rats

Sung Soo Kim; Mal Soon Shin; Hong Kim; Eun Kyung Kim; Hee Hyuk Lee; Hyun Kyung Chang; Taeck Hyun Lee; Mi Hyeon Jang; Min Chul Shin; Baek Vin Lim; Chang Ju Kim

doi:10.1002/nrc.20001

Treadmill exercise suppresses NPY expression in the hypothalamus of food-deprived rats

Sung Soo Kim, Mal Soon Shin, Hong Kim, Eun Kyung Kim, Hee Hyuk Lee, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Exercise has been known to potentially affect food intake. Neuropeptide Y (NPY) is a 36 amino acid peptide and concentrated in the hypothalamus which is an appetite-regulating area. NPY is known to stimulate appetite and decrease energy expenditure. In the present study, the effect of treadmill running on the NPY expression in the hypothalamus of food-deprived rats was investigated using immunohistochemistry. Enhanced NPY expression in the paraventricular nucleus (PVN) and arcuate nucleus (ARN) was observed in the food-deprived rats. Treadmill exercise suppressed the enhancement of NPY expression in the PVN and ARN following food deprivation, but this suppressive effect was not affected by exercise intensity. Based on the present results, it can be suggested that treadmill exercise is effective in limiting the enhancement of NPY expression following food-deprived conditions.

Original language	English (US)
Pages (from-to)	63-71
Number of pages	9
Journal	Neuroscience Research Communications
Volume	34
Issue number	2
DOIs	https://doi.org/10.1002/nrc.20001
State	Published - Mar 2004

Keywords

Arcuate nucleus
Neuropeptide Y
Paraventricular nucleus
Treadmill exercise

ASJC Scopus subject areas

General Neuroscience

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10.1002/nrc.20001

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title = "Treadmill exercise suppresses NPY expression in the hypothalamus of food-deprived rats",

abstract = "Exercise has been known to potentially affect food intake. Neuropeptide Y (NPY) is a 36 amino acid peptide and concentrated in the hypothalamus which is an appetite-regulating area. NPY is known to stimulate appetite and decrease energy expenditure. In the present study, the effect of treadmill running on the NPY expression in the hypothalamus of food-deprived rats was investigated using immunohistochemistry. Enhanced NPY expression in the paraventricular nucleus (PVN) and arcuate nucleus (ARN) was observed in the food-deprived rats. Treadmill exercise suppressed the enhancement of NPY expression in the PVN and ARN following food deprivation, but this suppressive effect was not affected by exercise intensity. Based on the present results, it can be suggested that treadmill exercise is effective in limiting the enhancement of NPY expression following food-deprived conditions.",

keywords = "Arcuate nucleus, Neuropeptide Y, Paraventricular nucleus, Treadmill exercise",

author = "Kim, {Sung Soo} and Shin, {Mal Soon} and Hong Kim and Kim, {Eun Kyung} and Lee, {Hee Hyuk} and Chang, {Hyun Kyung} and Lee, {Taeck Hyun} and Jang, {Mi Hyeon} and Shin, {Min Chul} and Lim, {Baek Vin} and Kim, {Chang Ju}",

year = "2004",

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AU - Kim, Sung Soo

AU - Shin, Mal Soon

AU - Kim, Hong

AU - Kim, Eun Kyung

AU - Lee, Hee Hyuk

AU - Chang, Hyun Kyung

AU - Lee, Taeck Hyun

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lim, Baek Vin

AU - Kim, Chang Ju

PY - 2004/3

Y1 - 2004/3

N2 - Exercise has been known to potentially affect food intake. Neuropeptide Y (NPY) is a 36 amino acid peptide and concentrated in the hypothalamus which is an appetite-regulating area. NPY is known to stimulate appetite and decrease energy expenditure. In the present study, the effect of treadmill running on the NPY expression in the hypothalamus of food-deprived rats was investigated using immunohistochemistry. Enhanced NPY expression in the paraventricular nucleus (PVN) and arcuate nucleus (ARN) was observed in the food-deprived rats. Treadmill exercise suppressed the enhancement of NPY expression in the PVN and ARN following food deprivation, but this suppressive effect was not affected by exercise intensity. Based on the present results, it can be suggested that treadmill exercise is effective in limiting the enhancement of NPY expression following food-deprived conditions.

AB - Exercise has been known to potentially affect food intake. Neuropeptide Y (NPY) is a 36 amino acid peptide and concentrated in the hypothalamus which is an appetite-regulating area. NPY is known to stimulate appetite and decrease energy expenditure. In the present study, the effect of treadmill running on the NPY expression in the hypothalamus of food-deprived rats was investigated using immunohistochemistry. Enhanced NPY expression in the paraventricular nucleus (PVN) and arcuate nucleus (ARN) was observed in the food-deprived rats. Treadmill exercise suppressed the enhancement of NPY expression in the PVN and ARN following food deprivation, but this suppressive effect was not affected by exercise intensity. Based on the present results, it can be suggested that treadmill exercise is effective in limiting the enhancement of NPY expression following food-deprived conditions.

KW - Arcuate nucleus

KW - Neuropeptide Y

KW - Paraventricular nucleus

KW - Treadmill exercise

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Treadmill exercise suppresses NPY expression in the hypothalamus of food-deprived rats

Abstract

Keywords

ASJC Scopus subject areas

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