Treadmill exercise suppresses ischemia-induced increment in apoptosis and cell proliferation in hippocampal dentate gyrus of gerbils

Myoung Hwa Lee, Hong Kim, Sung Soo Kim, Taeck Hyun Lee, Baek Vin Lim, Hyun Kyung Chang, Mi Hyeon Jang, Min Chul Shin, Mal Soon Shin, Chang Ju Kim

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42 Scopus citations

Abstract

Cerebral ischemia resulting from transient or permanent occlusion of cerebral arteries leads to neuronal cell death and eventually causes neurological impairments. In the present study, the effects of treadmill exercise on apoptosis and cell proliferation in the hippocampal dentate gyrus following transient global ischemia in gerbils were investigated using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay and immunohistochemistry for caspase-3 and 5-bromo-2′-deoxyuridine (BrdU). It was shown that apoptotic cell death and cell proliferation in the hippocampal dentate gyrus were significantly increased following transient global ischemia in gerbils and that treadmill exercise suppressed the ischemia-induced increase in apoptosis and cell proliferation in the dentate gyrus. The present results suggest that treadmill exercise may protect cells from apoptotic death and aid in recovery from the central nervous system sequelae following stroke.

Original languageEnglish (US)
Pages (from-to)2455-2465
Number of pages11
JournalLife Sciences
Volume73
Issue number19
DOIs
StatePublished - Sep 26 2003

Keywords

  • Apoptotic cell death
  • Cell proliferation
  • Transient global ischemia
  • Treadmill running

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Lee, M. H., Kim, H., Kim, S. S., Lee, T. H., Lim, B. V., Chang, H. K., Jang, M. H., Shin, M. C., Shin, M. S., & Kim, C. J. (2003). Treadmill exercise suppresses ischemia-induced increment in apoptosis and cell proliferation in hippocampal dentate gyrus of gerbils. Life Sciences, 73(19), 2455-2465. https://doi.org/10.1016/S0024-3205(03)00655-6