Treadmill exercise suppresses ischemia-induced increment in apoptosis and cell proliferation in hippocampal dentate gyrus of gerbils

Myoung Hwa Lee, Hong Kim, Sung Soo Kim, Taeck Hyun Lee, Baek Vin Lim, Hyun Kyung Chang, Mi-Hyeon D Jang, Min Chul Shin, Mal Soon Shin, Chang Ju Kim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Cerebral ischemia resulting from transient or permanent occlusion of cerebral arteries leads to neuronal cell death and eventually causes neurological impairments. In the present study, the effects of treadmill exercise on apoptosis and cell proliferation in the hippocampal dentate gyrus following transient global ischemia in gerbils were investigated using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay and immunohistochemistry for caspase-3 and 5-bromo-2′-deoxyuridine (BrdU). It was shown that apoptotic cell death and cell proliferation in the hippocampal dentate gyrus were significantly increased following transient global ischemia in gerbils and that treadmill exercise suppressed the ischemia-induced increase in apoptosis and cell proliferation in the dentate gyrus. The present results suggest that treadmill exercise may protect cells from apoptotic death and aid in recovery from the central nervous system sequelae following stroke.

Original languageEnglish (US)
Pages (from-to)2455-2465
Number of pages11
JournalLife Sciences
Volume73
Issue number19
DOIs
StatePublished - Sep 26 2003
Externally publishedYes

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Exercise equipment
Parahippocampal Gyrus
Gerbillinae
Dentate Gyrus
Cell proliferation
Cell Death
Ischemia
Cell Proliferation
Cell death
Apoptosis
Cerebral Arteries
DNA Nucleotidylexotransferase
Transient Ischemic Attack
Neurology
Bromodeoxyuridine
Caspase 3
Labeling
Assays
Central Nervous System
Immunohistochemistry

Keywords

  • Apoptotic cell death
  • Cell proliferation
  • Transient global ischemia
  • Treadmill running

ASJC Scopus subject areas

  • Pharmacology

Cite this

Treadmill exercise suppresses ischemia-induced increment in apoptosis and cell proliferation in hippocampal dentate gyrus of gerbils. / Lee, Myoung Hwa; Kim, Hong; Kim, Sung Soo; Lee, Taeck Hyun; Lim, Baek Vin; Chang, Hyun Kyung; Jang, Mi-Hyeon D; Shin, Min Chul; Shin, Mal Soon; Kim, Chang Ju.

In: Life Sciences, Vol. 73, No. 19, 26.09.2003, p. 2455-2465.

Research output: Contribution to journalArticle

Lee, Myoung Hwa ; Kim, Hong ; Kim, Sung Soo ; Lee, Taeck Hyun ; Lim, Baek Vin ; Chang, Hyun Kyung ; Jang, Mi-Hyeon D ; Shin, Min Chul ; Shin, Mal Soon ; Kim, Chang Ju. / Treadmill exercise suppresses ischemia-induced increment in apoptosis and cell proliferation in hippocampal dentate gyrus of gerbils. In: Life Sciences. 2003 ; Vol. 73, No. 19. pp. 2455-2465.
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