Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats

Hee Hyuk Lee, Hong Kim, Myoung Hwa Lee, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Mal Soon Shin, Young Pyo Kim, Jin Hwan Yoon, Il Gyu Jeong, Chang Ju Kim

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Intracerebral hemorrhage is one of the most devastating types of stroke. This disease is known to cause severe neurological damage and also has a very high mortality rate. In this study, the effect of treadmill exercise on intrastriatal hemorrhage-induced neuronal cell death was investigated. Intrastriatal hemorrhage was caused by injection of collagenase into the striatum using a stereotaxic instrument. Animals of the exercise group were made to run on a treadmill for 30 min once a day during 10 consecutive days. In the present results, treadmill exercise was shown to suppress the increase in the size of hemorrhage-induced lesions and the increase in caspase-3 expression in the striatum. Based on these results, it is possible that treadmill exercise aids in the recovery from central nervous system sequelae following intracerebral hemorrhage.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalNeuroscience Letters
Volume352
Issue number1
DOIs
StatePublished - Nov 27 2003

Keywords

  • Apoptosis
  • Caspase-3
  • Intrastriatal hemorrhage
  • Neuronal cell death
  • Treadmill running

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats'. Together they form a unique fingerprint.

  • Cite this

    Lee, H. H., Kim, H., Lee, M. H., Chang, H. K., Lee, T. H., Jang, M. H., Shin, M. C., Lim, B. V., Shin, M. S., Kim, Y. P., Yoon, J. H., Jeong, I. G., & Kim, C. J. (2003). Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats. Neuroscience Letters, 352(1), 33-36. https://doi.org/10.1016/j.neulet.2003.08.039