Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats

Hee Hyuk Lee; Hong Kim; Myoung Hwa Lee; Hyun Kyung Chang; Taeck Hyun Lee; Mi Hyeon Jang; Min Chul Shin; Baek Vin Lim; Mal Soon Shin; Young Pyo Kim; Jin Hwan Yoon; Il Gyu Jeong; Chang Ju Kim

doi:10.1016/j.neulet.2003.08.039

Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats

Hee Hyuk Lee, Hong Kim, Myoung Hwa Lee, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Mal Soon Shin, Young Pyo Kim, Jin Hwan Yoon, Il Gyu Jeong, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Intracerebral hemorrhage is one of the most devastating types of stroke. This disease is known to cause severe neurological damage and also has a very high mortality rate. In this study, the effect of treadmill exercise on intrastriatal hemorrhage-induced neuronal cell death was investigated. Intrastriatal hemorrhage was caused by injection of collagenase into the striatum using a stereotaxic instrument. Animals of the exercise group were made to run on a treadmill for 30 min once a day during 10 consecutive days. In the present results, treadmill exercise was shown to suppress the increase in the size of hemorrhage-induced lesions and the increase in caspase-3 expression in the striatum. Based on these results, it is possible that treadmill exercise aids in the recovery from central nervous system sequelae following intracerebral hemorrhage.

Original language	English (US)
Pages (from-to)	33-36
Number of pages	4
Journal	Neuroscience Letters
Volume	352
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2003.08.039
State	Published - Nov 27 2003

Keywords

Apoptosis
Caspase-3
Intrastriatal hemorrhage
Neuronal cell death
Treadmill running

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2003.08.039

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Lee, H. H., Kim, H., Lee, M. H., Chang, H. K., Lee, T. H., Jang, M. H., Shin, M. C., Lim, B. V., Shin, M. S., Kim, Y. P., Yoon, J. H., Jeong, I. G., & Kim, C. J. (2003). Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats. Neuroscience Letters, 352(1), 33-36. https://doi.org/10.1016/j.neulet.2003.08.039

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title = "Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats",

abstract = "Intracerebral hemorrhage is one of the most devastating types of stroke. This disease is known to cause severe neurological damage and also has a very high mortality rate. In this study, the effect of treadmill exercise on intrastriatal hemorrhage-induced neuronal cell death was investigated. Intrastriatal hemorrhage was caused by injection of collagenase into the striatum using a stereotaxic instrument. Animals of the exercise group were made to run on a treadmill for 30 min once a day during 10 consecutive days. In the present results, treadmill exercise was shown to suppress the increase in the size of hemorrhage-induced lesions and the increase in caspase-3 expression in the striatum. Based on these results, it is possible that treadmill exercise aids in the recovery from central nervous system sequelae following intracerebral hemorrhage.",

keywords = "Apoptosis, Caspase-3, Intrastriatal hemorrhage, Neuronal cell death, Treadmill running",

author = "Lee, {Hee Hyuk} and Hong Kim and Lee, {Myoung Hwa} and Chang, {Hyun Kyung} and Lee, {Taeck Hyun} and Jang, {Mi Hyeon} and Shin, {Min Chul} and Lim, {Baek Vin} and Shin, {Mal Soon} and Kim, {Young Pyo} and Yoon, {Jin Hwan} and Jeong, {Il Gyu} and Kim, {Chang Ju}",

note = "Funding Information: This work was supported by a Korea Research Foundation Grant (KRF-2003-050-G00005).",

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doi = "10.1016/j.neulet.2003.08.039",

language = "English (US)",

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T1 - Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats

AU - Lee, Hee Hyuk

AU - Kim, Hong

AU - Lee, Myoung Hwa

AU - Chang, Hyun Kyung

AU - Lee, Taeck Hyun

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lim, Baek Vin

AU - Shin, Mal Soon

AU - Kim, Young Pyo

AU - Yoon, Jin Hwan

AU - Jeong, Il Gyu

AU - Kim, Chang Ju

N1 - Funding Information: This work was supported by a Korea Research Foundation Grant (KRF-2003-050-G00005).

PY - 2003/11/27

Y1 - 2003/11/27

N2 - Intracerebral hemorrhage is one of the most devastating types of stroke. This disease is known to cause severe neurological damage and also has a very high mortality rate. In this study, the effect of treadmill exercise on intrastriatal hemorrhage-induced neuronal cell death was investigated. Intrastriatal hemorrhage was caused by injection of collagenase into the striatum using a stereotaxic instrument. Animals of the exercise group were made to run on a treadmill for 30 min once a day during 10 consecutive days. In the present results, treadmill exercise was shown to suppress the increase in the size of hemorrhage-induced lesions and the increase in caspase-3 expression in the striatum. Based on these results, it is possible that treadmill exercise aids in the recovery from central nervous system sequelae following intracerebral hemorrhage.

AB - Intracerebral hemorrhage is one of the most devastating types of stroke. This disease is known to cause severe neurological damage and also has a very high mortality rate. In this study, the effect of treadmill exercise on intrastriatal hemorrhage-induced neuronal cell death was investigated. Intrastriatal hemorrhage was caused by injection of collagenase into the striatum using a stereotaxic instrument. Animals of the exercise group were made to run on a treadmill for 30 min once a day during 10 consecutive days. In the present results, treadmill exercise was shown to suppress the increase in the size of hemorrhage-induced lesions and the increase in caspase-3 expression in the striatum. Based on these results, it is possible that treadmill exercise aids in the recovery from central nervous system sequelae following intracerebral hemorrhage.

KW - Apoptosis

KW - Caspase-3

KW - Intrastriatal hemorrhage

KW - Neuronal cell death

KW - Treadmill running

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Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats

Abstract

Keywords

ASJC Scopus subject areas

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