Transvenous, antegrade melody valve-in-valve implantation for bioprosthetic mitral and tricuspid valve dysfunction: A case series in children and adults

Michael W. Cullen, Allison K. Cabalka, Oluseun O. Alli, Sorin V. Pislaru, Paul Sorajja, Vuyisile T. Nkomo, Joseph F. Malouf, Frank Cetta, Donald J. Hagler, Charanjit S. Rihal

Research output: Contribution to journalArticle

104 Scopus citations

Abstract

Objectives The purpose of this study was to report the results of percutaneous valve-in-valve therapy using the Melody valve (Medtronic, Minneapolis, Minnesota) for patients with degenerated mitral and tricuspid bioprosthetic valves. Background Open surgery for replacement of degenerated bioprosthetic valves is associated with morbidity and mortality. Methods Nineteen patients (median age 65 years, range 10 to 88 years; 7 males) with degenerated mitral (n = 9) or tricuspid (n = 10) bioprosthetic valves underwent transvenous valve-in-valve implantation of the Melody valve. Results In the mitral patients, the mean Society of Thoracic Surgeons mortality score was 13.3 ± 5.6%. All patients had a prosthetic valve mean diastolic inflow gradient ≥5 mm Hg. Moderate or worse regurgitation was present in 7 of 9 mitral and 7 of 10 tricuspid patients. Implantation of a Melody valve was successful in all. Among the mitral patients, mean diastolic gradient decreased from 12.3 ± 4.6 mm Hg to 5.2 ± 2 mm Hg (p < 0.01). Residual regurgitation was trivial to mild in 6, mild to moderate in 2, and moderate in 1 patient. Among the tricuspid patients, mean diastolic gradient decreased from 10.0 ± 4.3 mm Hg to 5.6 ± 2.5 mm Hg (p < 0.01). Residual regurgitation was trivial to mild in 9 and mild to moderate in 1 patient. New York Heart Association functional class improved in 17 of 19 patients (p < 0.01). No periprocedural deaths, myocardial infarctions, strokes, or valve embolizations occurred. Vascular access site complications occurred in 4 patients. Conclusions Percutaneous valve-in-valve implantation of the Melody valve in the mitral or tricuspid position for treatment of bioprosthetic valve dysfunction is feasible and can lead to significant symptomatic improvement in carefully selected high-risk patients.

Original languageEnglish (US)
Pages (from-to)598-605
Number of pages8
JournalJACC: Cardiovascular Interventions
Volume6
Issue number6
DOIs
StatePublished - Jun 2013

Keywords

  • bioprosthetic valve
  • mitral stenosis
  • percutaneous valve
  • tricuspid stenosis
  • valve-in-valve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Transvenous, antegrade melody valve-in-valve implantation for bioprosthetic mitral and tricuspid valve dysfunction: A case series in children and adults'. Together they form a unique fingerprint.

  • Cite this