Transposon tools hopping in vertebrates

Jun Ni, Karl J. Clark, Scott C. Fahrenkrug, Stephen C. Ekker

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

In the past decade, tools derived from DNA transposons have made major contributions to vertebrate genetic studies from gene delivery to gene discovery. Multiple, highly complementary systems have been developed, and many more are in the pipeline. Judging which DNA transposon element will work the best in diverse uses from zebrafish genetic manipulation to human gene therapy is currently a complex task. We have summarized the major transposon vector systems active in vertebrates, comparing and contrasting known critical biochemical and in vivo properties, for future tool design and new genetic applications.

Original languageEnglish (US)
Pages (from-to)444-453
Number of pages10
JournalBriefings in Functional Genomics and Proteomics
Volume7
Issue number6
DOIs
StatePublished - Dec 1 2008

Keywords

  • Gene delivery
  • Gene discovery
  • Gene transfer vectors
  • Transposon
  • Vertebrates

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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