Transposon tools hopping in vertebrates

Jun Ni, Karl J Clark, Scott C. Fahrenkrug, Stephen C Ekker

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In the past decade, tools derived from DNA transposons have made major contributions to vertebrate genetic studies from gene delivery to gene discovery. Multiple, highly complementary systems have been developed, and many more are in the pipeline. Judging which DNA transposon element will work the best in diverse uses from zebrafish genetic manipulation to human gene therapy is currently a complex task. We have summarized the major transposon vector systems active in vertebrates, comparing and contrasting known critical biochemical and in vivo properties, for future tool design and new genetic applications.

Original languageEnglish (US)
Pages (from-to)444-453
Number of pages10
JournalBriefings in Functional Genomics and Proteomics
Volume7
Issue number6
DOIs
StatePublished - 2008

Fingerprint

DNA Transposable Elements
Vertebrates
Genes
Gene therapy
Genetic Association Studies
Zebrafish
Genetic Therapy
Pipelines

Keywords

  • Gene delivery
  • Gene discovery
  • Gene transfer vectors
  • Transposon
  • Vertebrates

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry

Cite this

Transposon tools hopping in vertebrates. / Ni, Jun; Clark, Karl J; Fahrenkrug, Scott C.; Ekker, Stephen C.

In: Briefings in Functional Genomics and Proteomics, Vol. 7, No. 6, 2008, p. 444-453.

Research output: Contribution to journalArticle

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