Transposition of the great arteries and hypocalcemia in a patient with fetal hydantoin syndrome

Mrugeshkumar K. Shah, Eva Morava, William Gill, Michael R. Marble

Research output: Contribution to journalArticle


We report a patient with fetal hydantoin syndrome (FHS) with associated d-transposition of the great arteries (d-TGA) and persistent hypocalcemia. d-TGA and hypocalcemia have each been individually reported once in association with FHS, but these patients were also prenatally exposed to phenobarbital. To our knowledge, this is the first report of these problems occurring after prenatal exposure to hydantoin alone. The combination of congenital heart disease and hypocalcemia in our patient raises the possibility of a hydantoin effect on neural crest migration.

Original languageEnglish (US)
Pages (from-to)89-90
Number of pages2
JournalJournal of Perinatology
Issue number1
StatePublished - Jan 1 2002


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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