Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Binsheng Wang, Zukai Liu, Vicky P. Chen, Lichao Wang, Christina L. Inman, Yueying Zhou, Chun Guo, Tamar Tchkonia, David W. Rowe, George A. Kuchel, Paul Robson, James L. Kirkland, Ming Xu

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Adipose-derived mesenchymal stem cell (ADSC)-based regenerative therapies have shown potential for use in many chronic diseases. Aging diminishes stem cell regenerative potential, yet it is unknown whether stem cells from aged donors cause adverse effects in recipients. ADSCs can be obtained using minimally invasive approaches and possess low immunogenicity. Nevertheless, we found that transplanting ADSCs from old donors, but not those from young donors, induces physical dysfunction in older recipient mice. Using single-cell transcriptomic analysis, we identified a naturally occurring senescent cell-like population in ADSCs primarily from old donors that resembles in vitro-generated senescent cells with regard to a number of key pathways. Our study reveals a previously unrecognized health concern due to ADSCs from old donors and lays the foundation for a new avenue of research to devise interventions to reduce harmful effects of ADSCs from old donors.

Original languageEnglish (US)
Article numbere13106
JournalAging Cell
Volume19
Issue number3
DOIs
StatePublished - Mar 1 2020

Keywords

  • aging
  • cellular senescence
  • frailty
  • regenerative medicine

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Fingerprint Dive into the research topics of 'Transplanting cells from old but not young donors causes physical dysfunction in older recipients'. Together they form a unique fingerprint.

  • Cite this

    Wang, B., Liu, Z., Chen, V. P., Wang, L., Inman, C. L., Zhou, Y., Guo, C., Tchkonia, T., Rowe, D. W., Kuchel, G. A., Robson, P., Kirkland, J. L., & Xu, M. (2020). Transplanting cells from old but not young donors causes physical dysfunction in older recipients. Aging Cell, 19(3), [e13106]. https://doi.org/10.1111/acel.13106