Transplantation Measured and Estimated GFR in Healthy Potential Kidney Donors

Andrew D Rule, Hiie M. Gussak, Gregory R. Pond, Erik J. Bergstralh, Mark D Stegall, Fernando G Cosio, Timothy S. Larson

Research output: Contribution to journalArticle

285 Citations (Scopus)

Abstract

Background: Nonradiolabeled iothalamate clearance is an accurate way to determine glomerular filtration rate (GFR). Objectives of this study are to define the normal range of nonradiolabeled iothalamate clearance in potential kidney donors and assess whether creatinine-based GFR estimates are accurate in this population. Methods: Medical records of 365 potential kidney donors were reviewed. GFR was measured using clearance of nonradiolabeled iothalamate. Linear regression analysis was used to determine age- and sex-specific normal range values for GFR and serum creatinine. The abbreviated Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault prediction equations were used to estimate GFR from serum creatinine levels. Results: GFR declined significantly with increasing age (P < 0.001) and was lower in women than men (P < 0.001). Men at the age of 20 years had an estimated mean GFR of 129 mL/min that declined by 4.6 mL/min/decade. Women at the age of 20 years had a mean GFR of 123 mL/min that declined by 7.1 mL/min/decade. Regression analysis of GFR normalized to body surface area (nGFR) was significant for age (P < 0.001), but not sex (P = 0.826). A 20-year-old had a mean nGFR of 111 mL/min/1.73 m 2 that declined by 4.9 mL/min/1.73 m2/decade. Correlation between measured nGFR and estimated GFR was weak (r = 0.26 for abbreviated MDRD equation; r = 0.35 for Cockcroft-Gault equation). Conclusion: This study of nonradiolabeled iothalamate clearance for the measurement of GFR in potential kidney donors established age-adjusted normal values. In healthy individuals, GFR cannot be estimated accurately using the abbreviated MDRD or Cockcroft-Gault prediction equations.

Original languageEnglish (US)
Pages (from-to)112-119
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume43
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Glomerular Filtration Rate
Transplantation
Tissue Donors
Kidney
Iothalamic Acid
Diet Therapy
Reference Values
Creatinine
Regression Analysis
Body Surface Area
Serum
Medical Records
Linear Models

Keywords

  • Creatinine
  • Glomerular filtration rate (GFR)
  • Iothalamic acid
  • Kidney
  • Living donor
  • Reference values

ASJC Scopus subject areas

  • Nephrology

Cite this

Transplantation Measured and Estimated GFR in Healthy Potential Kidney Donors. / Rule, Andrew D; Gussak, Hiie M.; Pond, Gregory R.; Bergstralh, Erik J.; Stegall, Mark D; Cosio, Fernando G; Larson, Timothy S.

In: American Journal of Kidney Diseases, Vol. 43, No. 1, 01.2004, p. 112-119.

Research output: Contribution to journalArticle

Rule, Andrew D ; Gussak, Hiie M. ; Pond, Gregory R. ; Bergstralh, Erik J. ; Stegall, Mark D ; Cosio, Fernando G ; Larson, Timothy S. / Transplantation Measured and Estimated GFR in Healthy Potential Kidney Donors. In: American Journal of Kidney Diseases. 2004 ; Vol. 43, No. 1. pp. 112-119.
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abstract = "Background: Nonradiolabeled iothalamate clearance is an accurate way to determine glomerular filtration rate (GFR). Objectives of this study are to define the normal range of nonradiolabeled iothalamate clearance in potential kidney donors and assess whether creatinine-based GFR estimates are accurate in this population. Methods: Medical records of 365 potential kidney donors were reviewed. GFR was measured using clearance of nonradiolabeled iothalamate. Linear regression analysis was used to determine age- and sex-specific normal range values for GFR and serum creatinine. The abbreviated Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault prediction equations were used to estimate GFR from serum creatinine levels. Results: GFR declined significantly with increasing age (P < 0.001) and was lower in women than men (P < 0.001). Men at the age of 20 years had an estimated mean GFR of 129 mL/min that declined by 4.6 mL/min/decade. Women at the age of 20 years had a mean GFR of 123 mL/min that declined by 7.1 mL/min/decade. Regression analysis of GFR normalized to body surface area (nGFR) was significant for age (P < 0.001), but not sex (P = 0.826). A 20-year-old had a mean nGFR of 111 mL/min/1.73 m 2 that declined by 4.9 mL/min/1.73 m2/decade. Correlation between measured nGFR and estimated GFR was weak (r = 0.26 for abbreviated MDRD equation; r = 0.35 for Cockcroft-Gault equation). Conclusion: This study of nonradiolabeled iothalamate clearance for the measurement of GFR in potential kidney donors established age-adjusted normal values. In healthy individuals, GFR cannot be estimated accurately using the abbreviated MDRD or Cockcroft-Gault prediction equations.",
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T1 - Transplantation Measured and Estimated GFR in Healthy Potential Kidney Donors

AU - Rule, Andrew D

AU - Gussak, Hiie M.

AU - Pond, Gregory R.

AU - Bergstralh, Erik J.

AU - Stegall, Mark D

AU - Cosio, Fernando G

AU - Larson, Timothy S.

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AB - Background: Nonradiolabeled iothalamate clearance is an accurate way to determine glomerular filtration rate (GFR). Objectives of this study are to define the normal range of nonradiolabeled iothalamate clearance in potential kidney donors and assess whether creatinine-based GFR estimates are accurate in this population. Methods: Medical records of 365 potential kidney donors were reviewed. GFR was measured using clearance of nonradiolabeled iothalamate. Linear regression analysis was used to determine age- and sex-specific normal range values for GFR and serum creatinine. The abbreviated Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault prediction equations were used to estimate GFR from serum creatinine levels. Results: GFR declined significantly with increasing age (P < 0.001) and was lower in women than men (P < 0.001). Men at the age of 20 years had an estimated mean GFR of 129 mL/min that declined by 4.6 mL/min/decade. Women at the age of 20 years had a mean GFR of 123 mL/min that declined by 7.1 mL/min/decade. Regression analysis of GFR normalized to body surface area (nGFR) was significant for age (P < 0.001), but not sex (P = 0.826). A 20-year-old had a mean nGFR of 111 mL/min/1.73 m 2 that declined by 4.9 mL/min/1.73 m2/decade. Correlation between measured nGFR and estimated GFR was weak (r = 0.26 for abbreviated MDRD equation; r = 0.35 for Cockcroft-Gault equation). Conclusion: This study of nonradiolabeled iothalamate clearance for the measurement of GFR in potential kidney donors established age-adjusted normal values. In healthy individuals, GFR cannot be estimated accurately using the abbreviated MDRD or Cockcroft-Gault prediction equations.

KW - Creatinine

KW - Glomerular filtration rate (GFR)

KW - Iothalamic acid

KW - Kidney

KW - Living donor

KW - Reference values

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