Transplantation in the sensitized recipient and across ABO blood groups

Carrie Schinstock; Mark Stegall

doi:10.1016/B978-0-323-53186-3.00022-X

Transplantation in the sensitized recipient and across ABO blood groups

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Alloantibody toward human leukocyte antigens (HLAs) and blood antigens is a major barrier to successful transplantation. This chapter discusses the current options for transplantation in sensitized renal transplant candidates or those with ABO-incompatible living donors. Specific emphasis is placed on what is known regarding the mechanisms and treatment of both early and late antibody-mediated injury, including the results of some recent therapeutic trials. Finally, current knowledge regarding the mechanism of antibody production in the setting of renal transplantation is outlined, highlighting important gaps in current knowledge in this emerging field.

Original language	English (US)
Title of host publication	Kidney Transplantation - Principles and Practice
Publisher	Elsevier
Pages	355-366
Number of pages	12
ISBN (Electronic)	9780323531863
DOIs	https://doi.org/10.1016/B978-0-323-53186-3.00022-X
State	Published - Jan 1 2019

Keywords

Crossmatch
Desensitization
Donor specific antibody
Kidney transplantation
Sensitized

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-323-53186-3.00022-X

Cite this

@inbook{6cbb78df795a41b4b7ab7dcfa584a258,

title = "Transplantation in the sensitized recipient and across ABO blood groups",

abstract = "Alloantibody toward human leukocyte antigens (HLAs) and blood antigens is a major barrier to successful transplantation. This chapter discusses the current options for transplantation in sensitized renal transplant candidates or those with ABO-incompatible living donors. Specific emphasis is placed on what is known regarding the mechanisms and treatment of both early and late antibody-mediated injury, including the results of some recent therapeutic trials. Finally, current knowledge regarding the mechanism of antibody production in the setting of renal transplantation is outlined, highlighting important gaps in current knowledge in this emerging field.",

keywords = "Crossmatch, Desensitization, Donor specific antibody, Kidney transplantation, Sensitized",

author = "Carrie Schinstock and Mark Stegall",

year = "2019",

month = jan,

day = "1",

doi = "10.1016/B978-0-323-53186-3.00022-X",

language = "English (US)",

pages = "355--366",

booktitle = "Kidney Transplantation - Principles and Practice",

publisher = "Elsevier",

}

TY - CHAP

T1 - Transplantation in the sensitized recipient and across ABO blood groups

AU - Schinstock, Carrie

AU - Stegall, Mark

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Alloantibody toward human leukocyte antigens (HLAs) and blood antigens is a major barrier to successful transplantation. This chapter discusses the current options for transplantation in sensitized renal transplant candidates or those with ABO-incompatible living donors. Specific emphasis is placed on what is known regarding the mechanisms and treatment of both early and late antibody-mediated injury, including the results of some recent therapeutic trials. Finally, current knowledge regarding the mechanism of antibody production in the setting of renal transplantation is outlined, highlighting important gaps in current knowledge in this emerging field.

AB - Alloantibody toward human leukocyte antigens (HLAs) and blood antigens is a major barrier to successful transplantation. This chapter discusses the current options for transplantation in sensitized renal transplant candidates or those with ABO-incompatible living donors. Specific emphasis is placed on what is known regarding the mechanisms and treatment of both early and late antibody-mediated injury, including the results of some recent therapeutic trials. Finally, current knowledge regarding the mechanism of antibody production in the setting of renal transplantation is outlined, highlighting important gaps in current knowledge in this emerging field.

KW - Crossmatch

KW - Desensitization

KW - Donor specific antibody

KW - Kidney transplantation

KW - Sensitized

UR - http://www.scopus.com/inward/record.url?scp=85093481426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85093481426&partnerID=8YFLogxK

U2 - 10.1016/B978-0-323-53186-3.00022-X

DO - 10.1016/B978-0-323-53186-3.00022-X

M3 - Chapter

AN - SCOPUS:85093481426

SP - 355

EP - 366

BT - Kidney Transplantation - Principles and Practice

PB - Elsevier

ER -

Transplantation in the sensitized recipient and across ABO blood groups

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this